Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 3/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | HTR1B | P28222 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
| ▸ | TYR | P14679 | 1/20 | 0.35 |
| ▸ | XDH | P47989 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3600818 | 0.78 | GAA (0.42) | PTGS1GABRA1GABRB2XDHKDM4E | |
| SCHEMBL9908791 | 0.76 | PTGS1 (0.45) | PTGS1TRPA1CACNA1CGABRA1GABRB2 | |
| SCHEMBL9029561 | 0.76 | PTGS1 (0.43) | PTGS1TRPA1CACNA1CGABRA1GABRB2 | |
| SCHEMBL1153449 | 0.75 | XDH (0.36) | PTGS1GABRA1GABRB2XDHKDM4E | |
| SCHEMBL9028340 | 0.72 | LMNA (0.43) | PTGS1TRPA1GABRA1GABRB2ADRA1A | |
| SCHEMBL28938963 | 0.71 | CYP3A4 (0.41) | PTGS1GABRA1GABRB2ADRA1AXDH | |
| SCHEMBL29115719 | 0.71 | PTPN1 (0.47) | PTGS1TRPA1GABRA1GABRB2XDH | |
| SCHEMBL9028025 | 0.71 | HTT (0.49) | PTGS1TRPA1GABRA1GABRB2XDH | |
| SCHEMBL9028982 | 0.70 | XDH (0.49) | PTGS1TRPA1CACNA1CGABRA1GABRB2 | |
| SCHEMBL11219745 | 0.69 | GAA (0.39) | PTGS1GABRA1GABRB2XDHKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445827-B1 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO KK (JP) | 1996-09-25 | — | — | EP | disclosed |
| US-5149834-A | Anticholesterol agent and enzyme inhibitors, for curing arteriosclerosis | FUJIREBIO INC. (JP) | 1992-09-22 | — | — | US | disclosed |
| EP-0445827-A2 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO INC. (JP) | 1991-09-11 | — | — | EP | disclosed |