Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 2/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.48 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.48 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.48 |
| ▸ | TYR | P14679 | 2/20 | 0.47 |
| ▸ | GABRA1 | P14867 | 5/20 | 0.46 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | CNR1 | P21554 | 2/20 | 0.38 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4314977 | 0.87 | TYR (0.46) | XDHPTGS1TRPA1CACNA1CTYR | |
| SCHEMBL9816379 | 0.86 | GABRA1 (0.59) | XDHPTGS1TRPA1CACNA1CTYR | |
| SCHEMBL873331 | 0.80 | LMNA (0.42) | XDHPTGS1TRPA1CACNA1CTYR | |
| SCHEMBL17120814 | 0.79 | TRPA1 (0.53) | PTGS1TRPA1CACNA1CTYRGABRA1 | |
| SCHEMBL1297588 | 0.79 | TRPA1 (0.57) | PTGS1TRPA1CACNA1CTYRGABRA1 | |
| SCHEMBL4109681 | 0.77 | TRPA1 (0.55) | PTGS1TRPA1CACNA1CTYRGABRA1 | |
| SCHEMBL4107540 | 0.76 | LMNA (0.47) | XDHPTGS1TRPA1CACNA1CTYR | |
| SCHEMBL25893405 | 0.76 | PPARG (0.36) | XDHPTGS1TRPA1CACNA1CTYR | |
| SCHEMBL11109370 | 0.76 | GABRA1 (0.54) | XDHPTGS1TRPA1GABRA1GABRB2 | |
| SCHEMBL1003895 | 0.76 | GABRA1 (0.50) | XDHPTGS1TRPA1GABRA1GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445827-B1 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO KK (JP) | 1996-09-25 | — | — | EP | disclosed |
| US-5149834-A | Anticholesterol agent and enzyme inhibitors, for curing arteriosclerosis | FUJIREBIO INC. (JP) | 1992-09-22 | — | — | US | disclosed |
| EP-0445827-A2 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO INC. (JP) | 1991-09-11 | — | — | EP | disclosed |