Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.32 |
| ▸ | TNKS | O95271 | 1/20 | 0.31 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.31 |
| ▸ | XDH | P47989 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9028429 | 0.89 | GABRA1 (0.35) | KDM4EGLAGAAGABRA1GABRB2 | |
| SCHEMBL9028520 | 0.77 | GAA (0.33) | KDM4EGLAGAAGABRA1GABRB2 | |
| SCHEMBL9028140 | 0.77 | KDM4E (0.38) | KDM4EGLAGAAGABRA1GABRB2 | |
| SCHEMBL9028182 | 0.75 | GABRA1 (0.33) | KDM4EGLAGAAGABRA1GABRB2 | |
| SCHEMBL9026750 | 0.70 | GABRA1 (0.39) | KDM4EGAAGABRA1GABRB2ALDH1A1 | |
| SCHEMBL9571652 | 0.69 | MAOB (0.33) | KDM4EGLAGAA | |
| SCHEMBL9571334 | 0.69 | MAOB (0.35) | KDM4EGLAGAA | |
| SCHEMBL9028435 | 0.69 | DHFR (0.37) | KDM4EGLAGAAGABRA1GABRB2 | |
| SCHEMBL9028192 | 0.69 | KDM4E (0.37) | KDM4EPTGS1 | |
| SCHEMBL9028185 | 0.68 | PRKCI (0.36) | KDM4EGLAGAAGABRA1GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445827-B1 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO KK (JP) | 1996-09-25 | — | — | EP | disclosed |
| US-5149834-A | Anticholesterol agent and enzyme inhibitors, for curing arteriosclerosis | FUJIREBIO INC. (JP) | 1992-09-22 | — | — | US | disclosed |
| EP-0445827-A2 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO INC. (JP) | 1991-09-11 | — | — | EP | disclosed |