Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 1/20 | 0.36 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | BCL2L2 | Q92843 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | LDHA | P00338 | 1/20 | 0.32 |
| ▸ | LDHB | P07195 | 1/20 | 0.32 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 2/20 | 0.31 |
| ▸ | ALB | P02768 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.31 |
| ▸ | APP | P05067 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14283810 | 0.75 | KDM4E (0.34) | LMNAMAOBHTTKDM4EMEN1 | |
| SCHEMBL9029561 | 0.75 | PTGS1 (0.43) | LMNAHTTTRPA1PTGS1CACNA1C | |
| SCHEMBL9027854 | 0.73 | CA1 (0.38) | LMNAHTTTRPA1PTGS1NPC1 | |
| SCHEMBL9028203 | 0.73 | HTT (0.41) | LMNALDHALDHBMAOBHTT | |
| SCHEMBL9028594 | 0.71 | LMNA (0.43) | LMNAHTTTRPA1NPC1HPGD | |
| SCHEMBL9028451 | 0.69 | SELL (0.39) | BCL2BCL2L1MCL1LMNAMAOB | |
| SCHEMBL9028429 | 0.68 | GABRA1 (0.35) | AKR1B1KDM4EMEN1KMT2A | |
| SCHEMBL9862023 | 0.68 | BCL2 (0.50) | BCL2BCL2L1MCL1BCL2L2LMNA | |
| SCHEMBL9405316 | 0.66 | CA1 (0.44) | LMNAMAOBKDM4EMEN1MAPT | |
| SCHEMBL658037 | 0.66 | PGK1 (0.34) | MAOBAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445827-B1 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO KK (JP) | 1996-09-25 | — | — | EP | disclosed |
| US-5149834-A | Anticholesterol agent and enzyme inhibitors, for curing arteriosclerosis | FUJIREBIO INC. (JP) | 1992-09-22 | — | — | US | disclosed |
| EP-0445827-A2 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO INC. (JP) | 1991-09-11 | — | — | EP | disclosed |