Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | XDH | P47989 | 1/20 | 0.31 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.30 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.30 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9571652 | 0.85 | MAOB (0.33) | MAOBAPPGAAKDM4EGLA | |
| SCHEMBL9571334 | 0.85 | MAOB (0.35) | MAOBAPPGAAKDM4EGLA | |
| SCHEMBL9028012 | 0.79 | MAOB (0.34) | MAOBGAAKDM4EGLAHPGD | |
| SCHEMBL21002168 | 0.78 | GAA (0.40) | MAOBAPPGAAKDM4EGLA | |
| SCHEMBL658037 | 0.78 | PGK1 (0.34) | MAOBAPPALDH1A1 | |
| SCHEMBL660212 | 0.78 | GAA (0.40) | MAOBAPPGAAKDM4EGLA | |
| SCHEMBL658062 | 0.75 | GAA (0.38) | MAOBAPPGAAKDM4EGLA | |
| SCHEMBL660261 | 0.75 | MAOB (0.30) | MAOB | |
| SCHEMBL2649487 | 0.75 | KDM4E (0.39) | MAOBAPPGAAKDM4EGLA | |
| SCHEMBL660484 | 0.74 | ALDH1A1 (0.37) | KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445827-B1 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO KK (JP) | 1996-09-25 | — | — | EP | disclosed |
| US-5266707-A | Anticholesterol | FUJIREBIO INC. (JP) | 1993-11-30 | — | — | US | disclosed |
| EP-0539709-A1 | 3,5-Dihydroxyheptanoic acid derivatives and lactones thereof as HMG-CoA reductase inhibitors | FUJIREBIO Inc. (JP) | 1993-05-05 | — | — | EP | disclosed |
| US-5149834-A | Anticholesterol agent and enzyme inhibitors, for curing arteriosclerosis | FUJIREBIO INC. (JP) | 1992-09-22 | — | — | US | disclosed |
| EP-0445827-A2 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO INC. (JP) | 1991-09-11 | — | — | EP | disclosed |