Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 11/20 | 0.48 |
| ▸ | NMT1 | P30419 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.39 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | HIPK1 | Q86Z02 | 1/20 | 0.39 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.39 |
| ▸ | HIPK3 | Q9H422 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.39 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL902750 | 0.88 | KARS1 (0.64) | KARS1NMT1HTR2CCLK1CLK2 | |
| SCHEMBL1704379 | 0.87 | KARS1 (0.62) | KARS1HTR2CMAP3K12 | |
| SCHEMBL901925 | 0.84 | KARS1 (0.67) | KARS1HTR2CMAP3K12 | |
| SCHEMBL1704501 | 0.82 | HTR2C (0.45) | KARS1NMT1HTR2CCLK1CLK2 | |
| Biphenyl SCHEMBL27906737 | 0.74 | RAB9A (0.56) | KARS1 | |
| SCHEMBL20919346 | 0.72 | KMT2A (0.57) | KARS1 | |
| SCHEMBL3114982 | 0.70 | SLC18A3 (0.68) | NMT1HTR2CSLC18A3SIGMAR1 | |
| SCHEMBL5668626 | 0.70 | MAPK1 (0.47) | HTR1AHTR7 | |
| SCHEMBL21565053 | 0.70 | MAPK1 (0.47) | HTR1AHTR7 | |
| SCHEMBL901665 | 0.70 | KARS1 (0.53) | KARS1MAP3K12CLK2DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | claimed |