Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 14/20 | 0.64 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.42 |
| ▸ | GSK3B | P49841 | 2/20 | 0.42 |
| ▸ | CLK1 | P49759 | 1/20 | 0.39 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
| ▸ | HIPK1 | Q86Z02 | 1/20 | 0.39 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.39 |
| ▸ | HIPK3 | Q9H422 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | NMT1 | P30419 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL902828 | 0.88 | KARS1 (0.48) | KARS1DYRK1ACLK1CLK2HIPK1 | |
| SCHEMBL1704379 | 0.84 | KARS1 (0.62) | KARS1HTR2C | |
| SCHEMBL901665 | 0.82 | KARS1 (0.53) | KARS1DYRK1AGSK3BCLK2 | |
| SCHEMBL901925 | 0.81 | KARS1 (0.67) | KARS1HTR2C | |
| SCHEMBL1704501 | 0.79 | HTR2C (0.45) | KARS1DYRK1AGSK3BCLK1CLK2 | |
| SCHEMBL901632 | 0.78 | KARS1 (1.00) | KARS1 | |
| SCHEMBL1705310 | 0.77 | KARS1 (0.48) | KARS1 | |
| SCHEMBL901538 | 0.75 | KARS1 (0.60) | KARS1HTR2C | |
| SCHEMBL902600 | 0.75 | KARS1 (1.00) | KARS1 | |
| SCHEMBL902190 | 0.73 | KARS1 (0.58) | KARS1CLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | claimed |
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |