Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 6/20 | 0.40 |
| ▸ | TACR2 | P21452 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.38 |
| ▸ | USP2 | O75604 | 3/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9027943 | 0.98 | TACR1 (0.41) | MAPTTACR1TACR2ALDH1A1TSHR | |
| SCHEMBL8885360 | 0.94 | TACR1 (0.45) | MAPTTACR1TACR2ALDH1A1TSHR | |
| SCHEMBL9028663 | 0.91 | MEN1 (0.38) | TACR1TACR2TSHRMEN1KMT2A | |
| SCHEMBL9027646 | 0.90 | TACR2 (0.42) | TACR1TACR2MEN1KMT2A | |
| SCHEMBL9027505 | 0.90 | TACR2 (0.42) | TACR1TACR2MEN1KMT2A | |
| SCHEMBL9028480 | 0.89 | MEN1 (0.40) | TACR1TSHRMEN1KMT2ACYP3A4 | |
| SCHEMBL9028382 | 0.89 | MEN1 (0.40) | TACR1TSHRMEN1KMT2ACYP3A4 | |
| SCHEMBL9028344 | 0.89 | MEN1 (0.40) | TACR1TSHRMEN1KMT2ACYP3A4 | |
| SCHEMBL9027486 | 0.89 | MEN1 (0.41) | TACR1TSHRMEN1KMT2ACYP3A4 | |
| SCHEMBL9026989 | 0.88 | CYP3A4 (0.38) | TACR1ALDH1A1TSHRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5563133-A | NERVOUS SYSTEM DISORDERS | ELI LILLY AND COMPANY (US) | 1996-10-08 | — | — | US | disclosed |
| EP-0714891-A1 | Heterocyclic tachykinin receptor antagonists | ELI LILLY AND COMPANY (US) | 1996-06-05 | — | — | EP | disclosed |