Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | HMGCR | P04035 | 1/20 | 0.35 |
| ▸ | XDH | P47989 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23387427 | 0.82 | HTT (0.46) | CYP19A1HTTALDH1A1NPC1HPGD | |
| SCHEMBL29115719 | 0.82 | PTPN1 (0.47) | ALDH1A1HPGDNPSR1GAAKDM4E | |
| SCHEMBL10356525 | 0.79 | DHFR (0.51) | HTTALDH1A1MAPK1GAAKDM4E | |
| SCHEMBL1744591 | 0.78 | KDM4E (0.40) | CYP19A1ALDH1A1HPGDNPSR1GAA | |
| SCHEMBL3600818 | 0.77 | GAA (0.42) | HTTALDH1A1NPC1HPGDMAPK1 | |
| SCHEMBL9028606 | 0.77 | HTT (0.41) | CYP19A1HTTALDH1A1NPC1HPGD | |
| SCHEMBL9027584 | 0.75 | MTNR1A (0.46) | ALDH1A1GAAKDM4EGABRA1GABRB2 | |
| SCHEMBL9743217 | 0.73 | HTT (0.56) | CYP19A1HTTALDH1A1NPC1HPGD | |
| SCHEMBL29108657 | 0.73 | TYR (0.42) | CYP19A1ALDH1A1HPGDNPSR1GAA | |
| SCHEMBL9028025 | 0.73 | HTT (0.49) | CYP19A1HTTALDH1A1NPC1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445827-B1 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO KK (JP) | 1996-09-25 | — | — | EP | disclosed |
| US-5149834-A | Anticholesterol agent and enzyme inhibitors, for curing arteriosclerosis | FUJIREBIO INC. (JP) | 1992-09-22 | — | — | US | disclosed |
| EP-0445827-A2 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO INC. (JP) | 1991-09-11 | — | — | EP | disclosed |