Sugi Predict

Sugi Predict / Compounds / SCHEMBL9028486

SCHEMBL9028486

SCHEMBL9028486

Cc1c2c(c(C=CC#N)c(C(C)C)c1OCc1ccccc1)OC(C)(C)C2

nearest known ligand 0.33

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ MAOB P27338 1/20 0.33
▸ MAP3K7 O43318 1/20 0.32
▸ TAB1 Q15750 1/20 0.32
▸ LMNA P02545 1/20 0.31
▸ GAA P10253 1/20 0.31
▸ HRH3 Q9Y5N1 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9722383 0.93 MAOB (0.33) MAOBMAP3K7TAB1LMNAGAA
SCHEMBL9028175 0.85 MAOB (0.38) MAOBLMNAGAA
SCHEMBL9028490 0.84 MAOB (0.32) MAOBMAP3K7TAB1LMNAGAA
SCHEMBL9028421 0.81 LMNA (0.33) MAOBMAP3K7TAB1LMNAGAA
SCHEMBL9028428 0.81 LMNA (0.33) MAOBMAP3K7TAB1LMNAGAA
SCHEMBL9722385 0.80 MAOB (0.32) MAOBMAP3K7TAB1LMNAGAA
SCHEMBL9027237 0.80 MAOB (0.33) MAOB
SCHEMBL9028467 0.80 MAOB (0.37) MAOBLMNAGAAHRH3
SCHEMBL8854971 0.80 MAOB (0.31) MAOB
SCHEMBL9028395 0.79 MAOB (0.38) MAOBLMNAGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0445827-B1 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents FUJIREBIO KK (JP) 1996-09-25 — — EP disclosed
US-5149834-A Anticholesterol agent and enzyme inhibitors, for curing arteriosclerosis FUJIREBIO INC. (JP) 1992-09-22 — — US disclosed