Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.62 |
| ▸ | CNR1 | P21554 | 3/20 | 0.62 |
| ▸ | CNR2 | P34972 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6042188 | 0.90 | CNR2 (0.70) | LMNACNR1CNR2ALDH1A1MAPT | |
| SCHEMBL9029183 | 0.85 | LMNA (0.68) | LMNACHRM1CNR1CNR2 | |
| SCHEMBL10656688 | 0.84 | CNR2 (0.76) | CNR1CNR2ALDH1A1MAPTTSHR | |
| SCHEMBL10086145 | 0.83 | ALDH1A1 (0.56) | LMNACHRM1CNR1CNR2ALDH1A1 | |
| SCHEMBL29874516 | 0.83 | LMNA (0.69) | LMNACHRM1CNR2 | |
| SCHEMBL9026679 | 0.82 | CNR2 (0.74) | LMNACNR1CNR2 | |
| SCHEMBL90348 | 0.82 | CNR2 (0.71) | LMNACNR1CNR2ALDH1A1MAPT | |
| SCHEMBL3450091 | 0.82 | ALDH1A1 (0.46) | LMNACHRM1CNR1CNR2ALDH1A1 | |
| SCHEMBL4154426 | 0.82 | KDM4E (0.55) | LMNACHRM1CNR1CNR2ALDH1A1 | |
| SCHEMBL1661468 | 0.81 | LMNA (0.71) | LMNACHRM1CNR2ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0494978-B1 | HETEROCYCLIC COMPOUNDS | WYETH JOHN & BROTHER LTD (GB) | 1996-02-28 | — | — | EP | disclosed |
| US-5362734-A | Certain benzo-quinolizine compounds and derivatives thereof | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-11-08 | — | — | US | disclosed |
| US-5225419-A | Antagonist 5-hydroxytryptamine for treatment of nausea or vomiting | JOHN WYETH & BROTHER, LIMITED (GB) | 1993-07-06 | — | — | US | disclosed |
| EP-0494978-A1 | HETEROCYCLIC COMPOUNDS. | WYETH JOHN & BROTHER LTD (GB) | 1992-07-22 | — | — | EP | disclosed |
| US-5096901-A | PHARMACOLOGICALLY ACTIVE AMIDES AND ESTERS CONTAINING AN AZABICYCLOALKANE MOIETY | JOHN WYETH & BROTHER LIMITED (GB) | 1992-03-17 | — | — | US | disclosed |
| WO-1991005783-A1 | HETEROCYCLIC COMPOUNDS | JOHN WYETH & BROTHER LIMITED (GB) | 1991-05-02 | — | — | WO | disclosed |