Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9029438 | 0.88 | BACE1 (0.47) | BACE1HTTPKMSMN1; SMN2KDM4E | |
| SCHEMBL17935193 | 0.78 | CA1 (0.46) | BACE1HTTCYP1A2ADRA2ACYP2D6 | |
| SCHEMBL9028778 | 0.77 | AKR1B1 (0.38) | HTTCYP1A2ADRA2ACYP2D6PKM | |
| SCHEMBL8176820 | 0.77 | FABP3 (0.52) | HTTRARGRXRAPPARG | |
| SCHEMBL6768274 | 0.77 | PREP (0.42) | BACE1HTTCYP1A2ADRA2ACYP2D6 | |
| SCHEMBL9270934 | 0.76 | FNTA (0.42) | HTTCYP1A2ADRA2ACYP2D6PKM | |
| SCHEMBL1928602 | 0.75 | GABRA1 (0.40) | HTTCYP1A2ADRA2ACYP2D6PKM | |
| SCHEMBL29113877 | 0.75 | HTT (0.38) | BACE1HTTCYP1A2ADRA2ACYP2D6 | |
| SCHEMBL6767046 | 0.74 | BACE1 (0.40) | BACE1SMN1; SMN2KDM4ETP53MAPT | |
| SCHEMBL9090807 | 0.74 | THRA (0.45) | BACE1KDM4ELMNAGAAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445827-B1 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO KK (JP) | 1996-09-25 | — | — | EP | disclosed |
| US-5149834-A | Anticholesterol agent and enzyme inhibitors, for curing arteriosclerosis | FUJIREBIO INC. (JP) | 1992-09-22 | — | — | US | disclosed |
| EP-0445827-A2 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO INC. (JP) | 1991-09-11 | — | — | EP | disclosed |