Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28682429 | 0.82 | MEN1 (0.41) | TSHRALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL27958818 | 0.79 | MEN1 (0.38) | TSHRALDH1A1GAALMNAMEN1 | |
| SCHEMBL5837362 | 0.78 | TSHR (0.53) | TSHRALDH1A1GAALMNAMEN1 | |
| SCHEMBL2649379 | 0.76 | KMT2A (0.36) | TSHRALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL2646640 | 0.76 | IMPDH2 (0.34) | TSHRALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL2650310 | 0.75 | TSHR (0.45) | TSHRALDH1A1GAALMNAMEN1 | |
| SCHEMBL7823512 | 0.74 | CYP1A2 (0.52) | TSHRALDH1A1MCL1KDM4EPABPC1 | |
| SCHEMBL29786760 | 0.74 | KMT2A (0.61) | TSHRALDH1A1GAALMNAMEN1 | |
| SCHEMBL982388 | 0.74 | KMT2A (0.61) | TSHRALDH1A1GAALMNAMEN1 | |
| SCHEMBL7823511 | 0.73 | TSHR (0.47) | TSHRKDM4EHSP90AA1L3MBTL1TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0703905-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO. INC. (US) | 1996-04-03 | — | — | EP | disclosed |