Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 3/20 | 0.44 |
| ▸ | ATR | Q13535 | 1/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 5/20 | 0.40 |
| ▸ | CDK1 | P06493 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | MTOR | P42345 | 2/20 | 0.38 |
| ▸ | SMG1 | Q96Q15 | 2/20 | 0.38 |
| ▸ | LARS1 | Q9P2J5 | 1/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | IDH1 | O75874 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.37 |
| ▸ | XBP1 | P17861 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CCND1 | P24385 | 1/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704681 | 0.82 | KARS1 (0.52) | KARS1CDK1CDK2MTORSMG1 | |
| SCHEMBL1704727 | 0.82 | KARS1 (0.54) | KARS1 | |
| SCHEMBL1704255 | 0.81 | KARS1 (0.52) | KARS1BRAF | |
| SCHEMBL901406 | 0.80 | KARS1 (0.50) | KARS1IRAK4CDK1CDK2MTOR | |
| SCHEMBL902454 | 0.77 | ASIC3 (0.42) | KARS1LARS1IDH1HTT | |
| SCHEMBL20974132 | 0.75 | KDM4D (0.40) | MAP4K4NPC1MAPTRAB9AHRH4 | |
| SCHEMBL15912936 | 0.70 | HRH3 (0.42) | MAPK1HRH4 | |
| SCHEMBL902758 | 0.69 | KARS1 (0.64) | KARS1MAP4K4NPC1MAPTHTT | |
| SCHEMBL1119549 | 0.68 | HRH3 (0.35) | ATRMAPTMAPK1HRH4 | |
| SCHEMBL1704492 | 0.68 | KARS1 (0.51) | KARS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |