Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 5/20 | 0.50 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 3/20 | 0.42 |
| ▸ | CDK2 | P24941 | 2/20 | 0.42 |
| ▸ | MTOR | P42345 | 2/20 | 0.42 |
| ▸ | SMG1 | Q96Q15 | 2/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CDK7 | P50613 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901307 | 0.81 | KARS1 (0.77) | KARS1NPC1MAPTHTTCDK7 | |
| SCHEMBL901754 | 0.80 | KARS1 (0.58) | KARS1CSNK2A1CDK1CDK2MTOR | |
| SCHEMBL902886 | 0.80 | KARS1 (0.44) | KARS1CSNK2A1CDK1CDK2MTOR | |
| SCHEMBL901724 | 0.78 | KARS1 (0.57) | KARS1 | |
| SCHEMBL1704345 | 0.78 | KARS1 (0.59) | KARS1 | |
| SCHEMBL901874 | 0.75 | ASIC3 (0.47) | ASIC3LARS1HRH4 | |
| SCHEMBL12469502 | 0.75 | KARS1 (0.74) | KARS1CDK1CDK2MTORSMG1 | |
| SCHEMBL902861 | 0.72 | NOS1 (0.53) | MAPTASIC3 | |
| SCHEMBL18342131 | 0.71 | KDM4D (0.46) | NPC1MAPTMAPK1RAB9AHRH4 | |
| SCHEMBL901741 | 0.70 | KARS1 (0.74) | KARS1NPC1MAPTHTTCDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |