Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.60 |
| ▸ | BACE1 | P56817 | 2/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.44 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.44 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.44 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.42 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | PPARA | Q07869 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9027495 | 0.87 | PTPN1 (0.50) | ALOX5BACE1PTPN1PTPN11PTPN2 | |
| SCHEMBL9028753 | 0.84 | ALOX5 (0.47) | ALOX5BACE1PTPN1PTPN11PTPN2 | |
| SCHEMBL28002757 | 0.80 | PTPN1 (0.51) | ALOX5PTPN1PTPN11PTPN2CYP4F2 | |
| SCHEMBL28898703 | 0.77 | KDM4E (0.51) | ALOX5BACE1LMNAMAPTCYP3A4 | |
| SCHEMBL13459450 | 0.77 | ACHE (0.54) | ALOX5LMNAMAPTCYP3A4KDM4E | |
| SCHEMBL28898701 | 0.76 | ALOX5 (0.48) | ALOX5BACE1CYP4F2CYP4A11LMNA | |
| SCHEMBL29113872 | 0.75 | ALOX5 (0.55) | ALOX5BACE1LMNACYP3A4PPARG | |
| SCHEMBL4015738 | 0.75 | ALOX5 (0.42) | ALOX5BACE1PTPN1PTPN11PTPN2 | |
| SCHEMBL27803184 | 0.74 | ALOX5 (0.41) | ALOX5BACE1PTPN1PTPN11PTPN2 | |
| SCHEMBL13924206 | 0.74 | ALOX5 (0.41) | ALOX5BACE1LMNAMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445827-B1 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO KK (JP) | 1996-09-25 | — | — | EP | disclosed |
| US-5149834-A | Anticholesterol agent and enzyme inhibitors, for curing arteriosclerosis | FUJIREBIO INC. (JP) | 1992-09-22 | — | — | US | disclosed |
| EP-0445827-A2 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO INC. (JP) | 1991-09-11 | — | — | EP | disclosed |