Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.35 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.35 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9029445 | 0.84 | ALOX5 (0.60) | ALOX5ALDH1A1PKMKMT2AMEN1 | |
| SCHEMBL9028786 | 0.80 | ALOX5 (0.37) | ALOX5ALDH1A1PKMKMT2AMEN1 | |
| SCHEMBL9027495 | 0.76 | PTPN1 (0.50) | ALOX5KDM4EHSD17B10BACE1PTPN1 | |
| SCHEMBL7525731 | 0.75 | VCAM1 (0.39) | ALDH1A1PKMKMT2AMEN1POLB | |
| SCHEMBL9028742 | 0.75 | THRB (0.40) | ALDH1A1PKMKMT2AMEN1POLB | |
| SCHEMBL9028534 | 0.70 | HSD17B10 (0.37) | ALDH1A1L3MBTL1GPR174KDM4EHPGD | |
| SCHEMBL19523892 | 0.69 | KMT2A (0.43) | ALDH1A1PKMKMT2AMEN1POLB | |
| SCHEMBL6711093 | 0.69 | KMT2A (0.43) | ALDH1A1PKMKMT2AMEN1POLB | |
| SCHEMBL7734483 | 0.68 | ALOX5 (0.32) | ALOX5ALDH1A1KDM4EHPGDMAPT | |
| SCHEMBL9028103 | 0.68 | MEN1 (0.35) | ALDH1A1PKMKMT2AMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445827-B1 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO KK (JP) | 1996-09-25 | — | — | EP | disclosed |
| US-5149834-A | Anticholesterol agent and enzyme inhibitors, for curing arteriosclerosis | FUJIREBIO INC. (JP) | 1992-09-22 | — | — | US | disclosed |
| EP-0445827-A2 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO INC. (JP) | 1991-09-11 | — | — | EP | disclosed |