Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.82 |
| ▸ | HTT | P42858 | 1/20 | 0.76 |
| ▸ | GAA | P10253 | 1/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.66 |
| ▸ | ACHE | P22303 | 1/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | MGLL | Q99685 | 1/20 | 0.61 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | NAMPT | P43490 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.59 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16695142 | 0.90 | SMN1; SMN2 (0.68) | SMN1; SMN2HTTGAATDP1ACHE | |
| SCHEMBL3284280 | 0.90 | SMN1; SMN2 (0.68) | SMN1; SMN2HTTGAATDP1ACHE | |
| SCHEMBL4724682 | 0.88 | SMN1; SMN2 (0.66) | SMN1; SMN2HTTGAATDP1ACHE | |
| SCHEMBL3004294 | 0.86 | SMN1; SMN2 (0.72) | SMN1; SMN2HTTGAATDP1POLB | |
| SCHEMBL1673861 | 0.86 | MAPT (0.73) | SMN1; SMN2GAAACHEMGLLHSD11B1 | |
| SCHEMBL4703216 | 0.85 | GAA (0.68) | SMN1; SMN2HTTGAATDP1POLB | |
| SCHEMBL3004296 | 0.85 | SMN1; SMN2 (0.70) | SMN1; SMN2HTTGAATDP1POLB | |
| SCHEMBL1720183 | 0.84 | MGLL (0.82) | ACHEPOLBALDH1A1MGLLHSD11B1 | |
| SCHEMBL27293260 | 0.84 | ACHE (0.62) | SMN1; SMN2HTTACHEPOLBALDH1A1 | |
| SCHEMBL11616794 | 0.84 | ACHE (0.71) | SMN1; SMN2ACHEMGLLHSD11B1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102159207-A | Substituted pyrrolidine-2-carboxamides | HOFFMANN LA ROCHE | 2011-08-17 | — | — | CN | disclosed |
| CN-102083792-A | Compounds comprising a cyclobutoxy group | UCB PHARMA SA | 2011-06-01 | — | — | CN | disclosed |
| EP-0527079-B1 | N-(isoquinolein-5-yl)-sulfonyl azacycloalkanes, their process of preparation and pharmaceutical compositions containing them | ADIR (FR) | 1996-10-23 | — | — | EP | disclosed |