Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | CA4 | P22748 | 2/20 | 0.37 |
| ▸ | CA9 | Q16790 | 2/20 | 0.37 |
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.37 |
| ▸ | EHMT1 | Q9H9B1 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | CNR2 | P34972 | 6/20 | 0.33 |
| ▸ | CNR1 | P21554 | 4/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9030008 | 1.00 | NPC1 (0.44) | NPC1L3MBTL1CA12CA1CA2 | |
| SCHEMBL104713 | 0.83 | NPC1 (0.48) | NPC1L3MBTL1CA12CA1CA9 | |
| SCHEMBL104712 | 0.83 | NPC1 (0.48) | NPC1L3MBTL1CA12CA1CA9 | |
| SCHEMBL1395649 | 0.80 | NPC1 (0.54) | NPC1L3MBTL1CA12CA1CA2 | |
| SCHEMBL1022195 | 0.80 | NPC1 (0.54) | NPC1L3MBTL1CA12CA1CA2 | |
| SCHEMBL1630772 | 0.80 | NPC1 (0.54) | NPC1L3MBTL1CA12CA1CA2 | |
| SCHEMBL4787589 | 0.73 | NPC1 (0.48) | NPC1L3MBTL1CA12CA1CA2 | |
| SCHEMBL10505799 | 0.73 | CHRNB2 (0.39) | CNR2CNR1PPARGPPARDPPARA | |
| SCHEMBL10505809 | 0.73 | CHRNB2 (0.39) | CNR2CNR1PPARGPPARDPPARA | |
| SCHEMBL15931520 | 0.73 | NPC1 (0.48) | NPC1L3MBTL1CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0609289-B1 | IMIDAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | UPJOHN CO (US) | 1996-07-17 | — | — | EP | disclosed |
| US-5442062-A | Treating hypertension, congestive heart failure | THE UPJOHN COMPANY (US) | 1995-08-15 | — | — | US | disclosed |
| EP-0609289-A1 | IMIDAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME. | UPJOHN CO (US) | 1994-08-10 | — | — | EP | disclosed |
| WO-1994017069-A1 | PYRAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF | THE UPJOHN COMPANY (US) | 1994-08-04 | — | — | WO | disclosed |
| EP-0540209-A1 | Imidazole derivatives and pharmaceutical compositions containing the same | THE UPJOHN COMPANY (US) | 1993-05-05 | — | — | EP | disclosed |
| WO-1993008193-A1 | IMIDAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | THE UPJOHN COMPANY (US) | 1993-04-29 | — | — | WO | disclosed |