Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 8/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9030937 | 0.81 | POLB (0.37) | PTGS1PTGS2ALOX5POLB | |
| SCHEMBL7201845 | 0.70 | ALOX5 (0.53) | CYP19A1PTGS1PTGS2NR3C1PGR | |
| SCHEMBL7199665 | 0.70 | ALOX5 (0.53) | CYP19A1PTGS1PTGS2NR3C1PGR | |
| SCHEMBL7199661 | 0.70 | ALOX5 (0.50) | CYP19A1PTGS1PTGS2NR3C1PGR | |
| SCHEMBL31561627 | 0.68 | NPSR1 (0.60) | CYP19A1PTGS1PTGS2ABCB1AR | |
| SCHEMBL31561660 | 0.68 | NPSR1 (0.60) | CYP19A1PTGS1PTGS2ABCB1AR | |
| SCHEMBL9030263 | 0.67 | PPARA (0.41) | ALOX5 | |
| SCHEMBL9769521 | 0.67 | CYP4F2 (0.42) | ALOX5 | |
| SCHEMBL4286687 | 0.66 | MAPT (0.54) | CYP19A1NR3C1PGRARPOLB | |
| SCHEMBL10897027 | 0.65 | CYP19A1 (0.44) | CYP19A1NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0513285-B1 | IMIDAZOL-2-YL DERIVATIVES OF SUBSTITUTED BICYCLIC COMPOUNDS AND PROCESS FOR THEIR PREPARATION | PHARMACIA SPA (IT) | 1996-01-24 | — | — | EP | disclosed |
| US-5356920-A | Anticholesterol, antilipemic agent | FARMITALIA CARLO ERBA SRL. (IT) | 1994-10-18 | — | — | US | disclosed |
| EP-0513285-A1 | IMIDAZOL-2-YL DERIVATIVES OF SUBSTITUTED BICYCLIC COMPOUNDS AND PROCESS FOR THEIR PREPARATION. | ERBA CARLO SPA (IT) | 1992-11-19 | — | — | EP | disclosed |
| WO-1992009582-A1 | IMIDAZOL-2-YL DERIVATIVES OF SUBSTITUTED BICYCLIC COMPOUNDS AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA SRL (IT) | 1992-06-11 | — | — | WO | disclosed |