Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.72 |
| ▸ | CA1 | P00915 | 2/20 | 0.61 |
| ▸ | CA2 | P00918 | 2/20 | 0.61 |
| ▸ | CA9 | Q16790 | 1/20 | 0.61 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.53 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 5/20 | 0.48 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.46 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.45 |
| ▸ | HNF4A | P41235 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | MYC | P01106 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23003 | 0.87 | TSHR (0.79) | TSHRCA1CA2CA9FOLH1 | |
| SCHEMBL9468088 | 0.86 | TSHR (0.68) | TSHRCA1CA2CA9FOLH1 | |
| SCHEMBL15796669 | 0.86 | TSHR (0.72) | TSHRCA1CA2CA9FOLH1 | |
| Ammonia Solution, Strong SCHEMBL27527756 | 0.85 | TSHR (0.76) | TSHRCA1CA2CA9FOLH1 | |
| SCHEMBL28370887 | 0.85 | TSHR (0.76) | TSHRCA1CA2CA9FOLH1 | |
| SCHEMBL2292722 | 0.84 | TSHR (0.74) | TSHRCA1CA2CA9FOLH1 | |
| SCHEMBL69041 | 0.84 | TSHR (1.00) | TSHRCA1CA2CA9FOLH1 | |
| SCHEMBL7759867 | 0.84 | TSHR (0.74) | TSHRCA1CA2CA9FOLH1 | |
| SCHEMBL29580520 | 0.84 | TSHR (0.74) | TSHRCA1CA2CA9FOLH1 | |
| SCHEMBL6030710 | 0.83 | TSHR (0.78) | TSHRCA1CA2CA9FOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0542554-B1 | Substituted N-biphenylyl lactams | ORTHO PHARMA CORP (US) | 1996-01-31 | — | — | EP | disclosed |
| US-5246940-A | Angoitensin II receptor antagonist for hypertension, stroke or diabetes | ORTHO PHARMACEUTICAL CORPORATION (US) | 1993-09-21 | — | — | US | disclosed |
| EP-0542554-A1 | Substituted N-biphenylyl lactams | ORTHO PHARMACEUTICAL CORPORATION (US) | 1993-05-19 | — | — | EP | disclosed |
| US-5182288-A | Angiotensin II receptor antagonists | ORTHO PHARMACEUTICAL CORPORATION (US) | 1993-01-26 | — | — | US | disclosed |