Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SCN4A | P35499 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | P2RX4 | Q99571 | 9/20 | 0.34 |
| ▸ | P2RX1 | P51575 | 4/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 4/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.32 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6312853 | 0.76 | LMNA (0.41) | LMNATSHRMAPK1SCN4ASCN5A | |
| SCHEMBL1248885 | 0.74 | LMNA (0.35) | LMNATSHRMAPK1SCN4ASCN5A | |
| SCHEMBL7414781 | 0.74 | LMNA (0.35) | LMNATSHRMAPK1SCN4ASCN5A | |
| SCHEMBL7518490 | 0.74 | LMNA (0.39) | LMNATSHRMAPK1SCN4ASCN5A | |
| SCHEMBL8769693 | 0.74 | LMNA (0.35) | LMNATSHRMAPK1SCN4ASCN5A | |
| SCHEMBL1246144 | 0.74 | LMNA (0.39) | LMNATSHRMAPK1SCN4ASCN5A | |
| SCHEMBL1249107 | 0.74 | MTNR1A (0.39) | LMNATSHRMAPK1SCN4ASCN5A | |
| SCHEMBL3732224 | 0.71 | P2RX4 (0.35) | LMNATSHRMAPK1SCN4ASCN5A | |
| SCHEMBL11534924 | 0.70 | KMT2A (0.41) | LMNATSHRMAPK1SCN4ASCN5A | |
| SCHEMBL9030962 | 0.69 | MAPT (0.38) | LMNATSHRMAPK1SCN4ASCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711287-A4 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO INC (US) | 1996-08-28 | — | — | EP | disclosed |
| EP-0711287-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO. INC. (US) | 1996-05-15 | — | — | EP | disclosed |