Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | HPGD | P15428 | 6/20 | 0.48 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | TP53 | P04637 | 4/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.47 |
| ▸ | MAOA | P21397 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | TERT | O14746 | 1/20 | 0.47 |
| ▸ | IKBKB | O14920 | 1/20 | 0.47 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL76097 | 0.74 | CYP2E1 (0.58) | SMN1; SMN2POLBALDH1A1HPGDMAPT | |
| SCHEMBL6962833 | 0.73 | SMN1; SMN2 (0.59) | SMN1; SMN2POLBL3MBTL1ALDH1A1HPGD | |
| SCHEMBL28127747 | 0.73 | ALOX5 (0.50) | SMN1; SMN2POLBL3MBTL1ALDH1A1HPGD | |
| SCHEMBL13617471 | 0.73 | ALDH1A1 (0.50) | SMN1; SMN2POLBALDH1A1HPGDMAPT | |
| SCHEMBL4244247 | 0.72 | SMN1; SMN2 (0.77) | SMN1; SMN2POLBL3MBTL1ALDH1A1HPGD | |
| SCHEMBL6952636 | 0.72 | SMN1; SMN2 (0.58) | SMN1; SMN2POLBL3MBTL1ALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL7373131 | 0.72 | SMN1; SMN2 (0.58) | SMN1; SMN2POLBL3MBTL1ALDH1A1HPGD | |
| SCHEMBL6958076 | 0.72 | SMN1; SMN2 (0.58) | SMN1; SMN2POLBL3MBTL1ALDH1A1HPGD | |
| SCHEMBL27471575 | 0.71 | SMN1; SMN2 (0.52) | SMN1; SMN2POLBL3MBTL1ALDH1A1HPGD | |
| SCHEMBL30872887 | 0.70 | ALDH1A1 (0.51) | SMN1; SMN2ALDH1A1HPGDMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0729466-A1 | PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE, DAVIS & COMPANY (US) | 1996-09-04 | — | — | EP | disclosed |
| EP-0729463-A1 | 5,6-DIHYDROPYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE DAVIS & COMPANY (US) | 1996-09-04 | — | — | EP | disclosed |
| WO-1995014014-A2 | PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE, DAVIS & COMPANY (US) | 1995-05-26 | — | — | WO | disclosed |
| US-4710513-A | Substituted pyranone inhibitors of cholesterol synthesis | MERCK & CO., INC. (US) | 1987-12-01 | — | — | US | disclosed |