Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 6/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12691880 | 0.94 | TSHR (0.59) | TSHRMAPK1ALDH1A1KDM4EGAA | |
| SCHEMBL10082091 | 0.86 | TSHR (0.68) | TSHRMAPK1ALDH1A1KDM4EGAA | |
| SCHEMBL899837 | 0.83 | TSHR (0.56) | TSHRMAPK1ALDH1A1KDM4EGAA | |
| Nucleozin SCHEMBL1225006 | 0.83 | NPC1 (0.61) | TSHRALDH1A1KDM4EGAALMNA | |
| Nucleozin SCHEMBL29360670 | 0.83 | NPC1 (0.61) | TSHRALDH1A1KDM4EGAALMNA | |
| SCHEMBL899570 | 0.82 | LMNA (0.67) | TSHRMAPK1ALDH1A1KDM4EGAA | |
| SCHEMBL10082093 | 0.81 | LMNA (0.57) | TSHRMAPK1ALDH1A1KDM4ELMNA | |
| SCHEMBL898748 | 0.81 | LMNA (0.57) | TSHRMAPK1ALDH1A1KDM4ELMNA | |
| SCHEMBL12691812 | 0.81 | ALDH1A1 (0.59) | TSHRMAPK1ALDH1A1KDM4EGAA | |
| SCHEMBL899632 | 0.81 | LMNA (0.57) | TSHRMAPK1ALDH1A1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2621920-B1 | NOVEL PIPERAZINE ANALOGS WITH SUBSTITUTED HETEROARYL GROUPS AS BROAD-SPECTRUM INFLUENZA ANTIVIRALS | BRISTOL MYERS SQUIBB CO (US) | 2016-01-27 | — | — | EP | disclosed |
| WO-2012044531-A1 | NOVEL PIPERAZINE ANALOGS WITH SUBSTITUTED HETEROARYL GROUPS AS BROAD-SPECTRUM INFLUENZA ANTIVIRALS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-04-05 | — | — | WO | disclosed |