Nucleozin

Nucleozin

SCHEMBL29360670

Cc1onc(-c2ccccc2)c1C(=O)N1CCN(c2ccc([N+](=O)[O-])cc2Cl)CC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 1/20 0.61
ALDH1A1 P00352 5/20 0.60
KDM4E B2RXH2 2/20 0.60
GAA P10253 1/20 0.60
SMN1; SMN2 Q16637 3/20 0.60
HTT P42858 2/20 0.60
USP2 O75604 1/20 0.59
KMT2A Q03164 1/20 0.58
TSHR P16473 4/20 0.56
MAPT P10636 1/20 0.56
LMNA P02545 3/20 0.55
TP53 P04637 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Nucleozin SCHEMBL1225006 1.00 NPC1 (0.61) NPC1ALDH1A1KDM4EGAASMN1; SMN2
SCHEMBL12691832 0.93 NPC1 (0.63) NPC1ALDH1A1KDM4EGAASMN1; SMN2
SCHEMBL1226271 0.92 ALDH1A1 (0.54) NPC1ALDH1A1KDM4EGAASMN1; SMN2
SCHEMBL2388044 0.91 ALDH1A1 (0.52) NPC1ALDH1A1KDM4EGAASMN1; SMN2
SCHEMBL15391486 0.91 PHGDH (0.52) NPC1ALDH1A1KDM4EGAASMN1; SMN2
SCHEMBL899570 0.90 LMNA (0.67) NPC1ALDH1A1KDM4EGAASMN1; SMN2
SCHEMBL898997 0.89 LMNA (0.58) NPC1ALDH1A1KDM4ESMN1; SMN2HTT
SCHEMBL899632 0.88 LMNA (0.57) NPC1ALDH1A1KDM4ESMN1; SMN2HTT
SCHEMBL10082093 0.88 LMNA (0.57) ALDH1A1KDM4ESMN1; SMN2HTTUSP2
SCHEMBL898748 0.88 LMNA (0.57) ALDH1A1KDM4ESMN1; SMN2HTTUSP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 82 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116942832-A Novel anti-infective strategy for combined infection of influenza virus and staphylococcus aureus 归属疗法有限公司 2023-10-27 CN claimed
CN-116904567-A Rapid respiratory tract sample detection panel based on nanopore sequencing 上海市东方医院(同济大学附属东方医院) 2023-10-20 CN claimed
WO-2023036209-A1 REPLICATION-DEFECTIVE DRUG-RESISTANT INFLUENZA VIRUS AND METHOD FOR DETECTING RECOMBINATION RATE OF NUCLEIC ACID SEGMENT THEREOF 北京大学 2023-03-16 WO claimed
EP-4090686-A2 PRO-ANTIBODY THAT REDUCES OFF-TARGET TOXICITY Aetio Biotherapy, Inc. (US) 2022-11-23 EP claimed
US-20220096590-A1 NOVEL-ANTI-INFECTIVE STRATEGY AGAINST INFLUENZA VIRUS AND S. AUREUS COINFECTIONS ATRIVA THERAPEUTICS GMBH (DE) 2022-03-31 US claimed
WO-2026047214-A1 MODULATORS OF THE MITOTIC CELL CYCLE IN CANCER CELLS AND USES THEREOF FOR THE TREATMENT OF CANCER CHEMOTHERAPEUTISCHES FORSCHUNGSINSTITUT GEORG-SPEYER-HAUS (DE) 2026-03-05 WO disclosed
EP-4703725-A1 MODULATORS OF THE MITOTIC CELL CYCLE IN CANCER CELLS AND USES THEREOF FOR THE TREATMENT OF CANCER Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus (DE) 2026-03-04 EP disclosed
EP-4656588-A2 ENHANCED NANOPARTICLE DELIVERY SYSTEMS Children's Hospital Medical Center (US) 2025-12-03 EP disclosed
CN-120904125-A Nucleozin dimer derivative and preparation method and application thereof 湖南千金湘江药业股份有限公司 2025-11-07 CN disclosed
CN-120904125-A Nucleozin dimer derivative and preparation method and application thereof 湖南千金湘江药业股份有限公司 2025-11-07 CN disclosed
US-20250340879-A1 COMPOSITIONS AND METHODS FOR NUCLEIC ACID TRANSFER CHILDRENS HOSPITAL MED CT (US) 2025-11-06 US disclosed
EP-3973960-B1 NOVEL MEK-INHIBITOR FOR THE TREATMENT OF VIRAL AND BACTERIAL INFECTIONS ATRIVA THERAPEUTICS GMBH (DE) 2025-09-03 EP disclosed
CN-114269381-A Antibodies and methods for treating influenza a infection 胡默波斯生物医学公司 2022-04-01 CN disclosed
US-20220096590-A1 NOVEL-ANTI-INFECTIVE STRATEGY AGAINST INFLUENZA VIRUS AND S. AUREUS COINFECTIONS ATRIVA THERAPEUTICS GMBH (DE) 2022-03-31 US disclosed
EP-3973960-A1 NOVEL MEK-INHIBITOR FOR THE TREATMENT OF VIRAL AND BACTERIAL INFECTIONS Atriva Therapeutics GmbH (DE) 2022-03-30 EP disclosed
EP-3962530-A1 ANTIBODIES AND METHODS FOR TREATMENT OF INFLUENZA A INFECTION Humabs Biomed SA (CH) 2022-03-09 EP disclosed
CN-109414432-B Antimicrobial compounds and methods of use thereof 港大科桥有限公司 2022-03-08 CN disclosed
EP-3955908-A1 NOVEL MEK-INHIBITOR FOR THE TREATMENT OF VIRAL AND BACTERIAL INFECTIONS Atriva Therapeutics GmbH (DE) 2022-02-23 EP disclosed
CN-114007598-A Novel MEK inhibitors for the treatment of viral and bacterial infections 归属疗法有限公司 2022-02-01 CN disclosed
EP-3941464-A1 RSK INHIBITORS IN THE TREATMENT OF VIRUS DISEASES Atriva Therapeutics GmbH (DE) 2022-01-26 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220096590-A1 NOVEL-ANTI-INFECTIVE STRATEGY AGAINST INFLUENZA VIRUS AND S. AUREUS COINFECTIONS MAPK1, MAP2K1, MAP2K6 NPC1 3667/4885ALDH1A1 4386/4885KDM4E 3002/4885
US-20250340879-A1 COMPOSITIONS AND METHODS FOR NUCLEIC ACID TRANSFER SNRPE, RNASE1, POLRMT NPC1 46/4885ALDH1A1 3222/4885KDM4E 4493/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.