Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGM | P11217 | 2/20 | 0.42 |
| ▸ | PYGL | P06737 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.36 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.36 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.36 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | SIRT3 | Q9NTG7 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9032030 | 0.87 | KDM4E (0.47) | PYGMPYGLKDM4EGAAADORA3 | |
| SCHEMBL9033367 | 0.85 | PYGM (0.52) | PYGMPYGLKDM4EGAAADORA3 | |
| SCHEMBL9033030 | 0.84 | CACNA1C (0.43) | KDM4EGAAADORA3ALDH1A1CACNA1F | |
| SCHEMBL9032312 | 0.83 | KDM4E (0.50) | PYGMPYGLKDM4EGAAADORA3 | |
| SCHEMBL9031643 | 0.82 | CYP2C9 (0.44) | PYGMPYGLKDM4EGAAADORA3 | |
| SCHEMBL9033159 | 0.80 | ADORA3 (0.50) | PYGMPYGLKDM4EGAAADORA3 | |
| SCHEMBL9033145 | 0.79 | POLB (0.54) | PYGMPYGLKDM4EGAAADORA3 | |
| SCHEMBL9427365 | 0.76 | GPBAR1 (0.40) | PYGMPYGLKDM4EGAAALDH1A1 | |
| SCHEMBL9031541 | 0.76 | CYP1A2 (0.50) | ADORA3CACNA1BLMNACACNA1FCACNA1D | |
| SCHEMBL9031530 | 0.76 | CYP1A2 (0.50) | ADORA3CACNA1BLMNACACNA1FCACNA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0474129-B1 | 1,4-Dihydropyridine derivatives and process for preparing the same | ACHIWA KAZUO (JP) | 1996-12-18 | — | — | EP | disclosed |
| US-5336774-A | 1,4-dihydropyridine 3,5 carboxyl compounds | ACHIWA KAZUO (JP) | 1994-08-09 | — | — | US | disclosed |
| US-5234821-A | Process for preparing 1,4 dihydropyridine compounds | ACHIWA KAZUO (JP) | 1993-08-10 | — | — | US | disclosed |
| EP-0474129-A2 | 1,4-Dihydropyridine derivatives and process for preparing the same | Achiwa, Kazuo (JP) | 1992-03-11 | — | — | EP | disclosed |