Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 2/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9033666 | 0.83 | KDM4E (0.56) | MEN1KMT2AALOX15NPC1RAB9A | |
| SCHEMBL9034890 | 0.81 | ALOX15 (0.46) | MCHR1ADRA2AMAOBMEN1KMT2A | |
| SCHEMBL9032661 | 0.80 | MEN1 (0.51) | MEN1KMT2AHCRTR1ALOX15NPC1 | |
| SCHEMBL16832665 | 0.78 | KDM4E (0.57) | S1PR1OPRD1MEN1KMT2ANPC1 | |
| SCHEMBL9033128 | 0.75 | NPC1 (0.50) | MAOBMEN1KMT2AALOX15NPC1 | |
| SCHEMBL28530337 | 0.73 | KDM4E (0.53) | S1PR1OPRD1MEN1KMT2ANPC1 | |
| SCHEMBL3446883 | 0.71 | PARP1 (0.59) | MAOBMEN1KMT2AALOX15NPC1 | |
| SCHEMBL28520672 | 0.70 | ALOX15 (0.51) | MEN1KMT2AALOX15NPC1RAB9A | |
| SCHEMBL9034040 | 0.70 | ADORA2A (0.46) | S1PR1OPRD1MAOBALDH1A1KDM4E | |
| SCHEMBL6457843 | 0.70 | S1PR1 (0.52) | S1PR1OPRD1MAOBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5589484-A | TREATMENT OF HELICOBACTER INFECTIONS, ANTIULCER | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-12-31 | — | — | US | disclosed |
| EP-0666855-B1 | 4-QUINOLINYL DERIVATIVES WITH ANTI-HELICOBACTER ACTIVITY | JANSSEN PHARMACEUTICA NV (BE) | 1996-09-18 | — | — | EP | disclosed |
| EP-0666855-A1 | 4-QUINOLINYL DERIVATIVES WITH ANTI-HELICOBACTER ACTIVITY. | JANSSEN PHARMACEUTICA NV (BE) | 1995-08-16 | — | — | EP | disclosed |
| WO-1994010164-A1 | 4-QUINOLINYL DERIVATIVES WITH ANTI-HELICOBACTER ACTIVITY | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-05-11 | — | — | WO | disclosed |