Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.50 |
| ▸ | FADS1 | O60427 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | CTSV | O60911 | 1/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.45 |
| ▸ | CTSS | P25774 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TACR1 | P25103 | 2/20 | 0.43 |
| ▸ | VNN1 | O95497 | 1/20 | 0.43 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.43 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.43 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17151063 | 0.83 | ALDH1A1 (0.48) | ALDH1A1HPGDHTTNPSR1MEN1 | |
| SCHEMBL5591940 | 0.81 | KDM4E (0.50) | MAPK1ALDH1A1HTTNPSR1MEN1 | |
| SCHEMBL10112866 | 0.80 | RECQL (0.47) | NPC1RAB9AFADS1CTSVCTSL | |
| SCHEMBL9033666 | 0.80 | KDM4E (0.56) | NPC1RAB9AALOX15ALDH1A1HPGD | |
| SCHEMBL23193358 | 0.79 | NCF1 (0.50) | NPC1RAB9A | |
| SCHEMBL5234876 | 0.78 | CYP1A2 (0.49) | NPC1RAB9APSMD14MAPK1CTDSP1 | |
| SCHEMBL9034890 | 0.78 | ALOX15 (0.46) | NPC1RAB9APSMD14MAPK1CTDSP1 | |
| SCHEMBL3446883 | 0.76 | PARP1 (0.59) | NPC1RAB9AMAOBALOX15ALDH1A1 | |
| SCHEMBL9032661 | 0.75 | MEN1 (0.51) | NPC1RAB9AALOX15ALDH1A1TACR3 | |
| SCHEMBL9033595 | 0.75 | MCHR1 (0.48) | NPC1RAB9APSMD14MAPK1CTDSP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5589484-A | TREATMENT OF HELICOBACTER INFECTIONS, ANTIULCER | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-12-31 | — | — | US | disclosed |
| EP-0666855-B1 | 4-QUINOLINYL DERIVATIVES WITH ANTI-HELICOBACTER ACTIVITY | JANSSEN PHARMACEUTICA NV (BE) | 1996-09-18 | — | — | EP | disclosed |
| EP-0666855-A1 | 4-QUINOLINYL DERIVATIVES WITH ANTI-HELICOBACTER ACTIVITY. | JANSSEN PHARMACEUTICA NV (BE) | 1995-08-16 | — | — | EP | disclosed |
| WO-1994010164-A1 | 4-QUINOLINYL DERIVATIVES WITH ANTI-HELICOBACTER ACTIVITY | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-05-11 | — | — | WO | disclosed |