Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 2/20 | 0.39 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.30 |
| ▸ | GSK3A | P49840 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9033821 | 1.00 | KCNN4 (0.39) | KCNN4AGTR1MEN1KMT2AALDH1A1 | |
| SCHEMBL9033772 | 0.82 | AGTR1 (0.41) | KCNN4AGTR1MEN1KMT2AALDH1A1 | |
| SCHEMBL30743612 | 0.76 | ABCG2 (0.55) | AGTR1ALDH1A1HPGDPOLBSMN1; SMN2 | |
| SCHEMBL9429714 | 0.75 | ABCG2 (0.36) | KCNN4AGTR1POLBSMN1; SMN2ABCG2 | |
| SCHEMBL16370823 | 0.75 | AGTR1 (0.43) | KCNN4AGTR1ALDH1A1HPGDPOLB | |
| SCHEMBL29954781 | 0.74 | SMN1; SMN2 (0.37) | AGTR1ALDH1A1HPGDPOLBSMN1; SMN2 | |
| SCHEMBL8402419 | 0.74 | POLB (0.40) | AGTR1ALDH1A1HPGDPOLBSMN1; SMN2 | |
| Water SCHEMBL27471533 | 0.73 | ABCG2 (0.36) | AGTR1POLBSMN1; SMN2ABCG2RAB9A | |
| SCHEMBL4638378 | 0.72 | SMN1; SMN2 (0.51) | ALDH1A1HPGDPOLBSMN1; SMN2TSHR | |
| SCHEMBL4638349 | 0.71 | AGTR1 (0.47) | AGTR1MEN1KMT2AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0682654-A4 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE. | MERCK & CO INC (US) | 1996-01-17 | — | — | EP | disclosed |
| EP-0682654-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO. INC. (US) | 1995-11-22 | — | — | EP | disclosed |
| US-5284841-A | Benzo-fused lactams promote release of growth hormone | MERCK & CO., INC. (US) | 1994-02-08 | — | — | US | disclosed |