Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 2/20 | 0.38 |
| ▸ | XDH | P47989 | 1/20 | 0.37 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6155 | 0.86 | POLB (0.39) | AGTR1GRM5XDHKCNN4POLB | |
| SCHEMBL6188044 | 0.82 | GRM5 (0.39) | GRM5XDHKCNN4POLBSMN1; SMN2 | |
| SCHEMBL9033821 | 0.82 | KCNN4 (0.39) | AGTR1KCNN4POLBSMN1; SMN2ABCG2 | |
| SCHEMBL9033829 | 0.82 | KCNN4 (0.39) | AGTR1KCNN4POLBSMN1; SMN2ABCG2 | |
| SCHEMBL4638150 | 0.81 | AGTR1 (0.45) | AGTR1XDHPOLBSMN1; SMN2ABCG2 | |
| SCHEMBL30743612 | 0.79 | ABCG2 (0.55) | AGTR1GRM5POLBSMN1; SMN2ABCG2 | |
| SCHEMBL16370823 | 0.78 | AGTR1 (0.43) | AGTR1KCNN4POLBSMN1; SMN2ABCG2 | |
| SCHEMBL9429714 | 0.78 | ABCG2 (0.36) | AGTR1KCNN4POLBSMN1; SMN2ABCG2 | |
| SCHEMBL8784604 | 0.78 | ABCG2 (0.39) | AGTR1GRM5XDHPOLBSMN1; SMN2 | |
| SCHEMBL8402419 | 0.77 | POLB (0.40) | AGTR1POLBSMN1; SMN2ABCG2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0682654-A4 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE. | MERCK & CO INC (US) | 1996-01-17 | — | — | EP | disclosed |
| EP-0682654-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO. INC. (US) | 1995-11-22 | — | — | EP | disclosed |
| WO-1994018169-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1994-08-18 | — | — | WO | disclosed |
| US-5284841-A | Benzo-fused lactams promote release of growth hormone | MERCK & CO., INC. (US) | 1994-02-08 | — | — | US | disclosed |