SCHEMBL9033853

SCHEMBL9033853

C=CON([C]=O)c1ccccc1

nearest known ligand 0.33

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.31
NPSR1 Q6W5P4 1/20 0.31
ALOX15 P16050 1/20 0.31
MEN1 O00255 1/20 0.30
HTT P42858 1/20 0.30
KMT2A Q03164 1/20 0.30
TSHR P16473 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1335024 0.72 KMT2A (0.38) ALDH1A1NPSR1ALOX15MEN1HTT
SCHEMBL621536 0.71 L3MBTL1 (0.39) ALDH1A1NPSR1ALOX15MEN1HTT
SCHEMBL2393161 0.68 ALDH1A1 (0.34) ALDH1A1NPSR1ALOX15MEN1HTT
SCHEMBL8392430 0.68 MEN1 (0.34) ALDH1A1NPSR1ALOX15MEN1HTT
SCHEMBL4634276 0.68 ALDH1A1 (0.38) ALDH1A1NPSR1MEN1HTTKMT2A
SCHEMBL8782806 0.67 APOBEC3G (0.41) ALDH1A1KMT2A
SCHEMBL3246276 0.67 NPSR1 (0.39) ALDH1A1NPSR1MEN1KMT2ATSHR
SCHEMBL277885 0.64 ESR1 (0.41) ALDH1A1MEN1KMT2ATSHR
SCHEMBL6002568 0.63 TACR1 (0.30)
SCHEMBL104821 0.63 ALDH1A1 (0.42) ALDH1A1NPSR1ALOX15MEN1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0705834-A1 Quinoxaline-2,3-diones with an azaheterocyclic fused ring CIBA-GEIGY AG (CH) 1996-04-10 EP disclosed
EP-0705835-A1 Quinoxalic-2,3-diones with an oxa or thiaheterocyclic fused ring CIBA-GEIGY AG (CH) 1996-04-10 EP disclosed