Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfuric Acid SCHEMBL9032305 | 0.88 | KCNH2 (0.35) | KCNH2 | |
| SCHEMBL7388072 | 0.87 | KCNH2 (0.48) | KCNH2 | |
| Hydrochloric Acid SCHEMBL7359212 | 0.86 | KCNH2 (0.48) | KCNH2 | |
| SCHEMBL9039225 | 0.81 | KCNH2 (0.32) | KCNH2 | |
| Hydrochloric Acid SCHEMBL9041198 | 0.74 | KCNH2 (0.37) | KCNH2 | |
| Hydrochloric Acid SCHEMBL8564106 | 0.74 | ADRA1D (0.37) | KCNH2 | |
| SCHEMBL9039873 | 0.73 | KCNH2 (0.50) | KCNH2 | |
| SCHEMBL8831682 | 0.72 | KCNH2 (0.55) | KCNH2 | |
| SCHEMBL3457612 | 0.71 | ADRA1D (0.37) | ALDH1A1 | |
| Hydrochloric Acid SCHEMBL8832193 | 0.71 | KCNH2 (0.54) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0683782-A4 | SPIRO (2H-1-BENZOPYRAN-2, 4' PIPERIDINE) CLASS III ANTIARRHYTHMICS. | MERCK & CO INC (US) | 1996-03-27 | — | — | EP | disclosed |
| EP-0683782-A1 | SPIRO (2H-1-BENZOPYRAN-2, 4' PIPERIDINE) CLASS III ANTIARRHYTHMICS | MERCK & CO. INC. (US) | 1995-11-29 | — | — | EP | disclosed |
| WO-1994018204-A1 | SPIRO (2H-1-BENZOPYRAN-2, 4' PIPERIDINE) CLASS III ANTIARRHYTHMICS | MERCK & CO., INC. (US) | 1994-08-18 | — | — | WO | disclosed |