Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 5/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | CCR1 | P32246 | 2/20 | 0.40 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18282707 | 0.85 | OPRL1 (0.55) | OPRL1OPRM1OPRD1OPRK1DRD2 | |
| SCHEMBL7669838 | 0.82 | MAPT (0.48) | HSD11B1 | |
| SCHEMBL24394078 | 0.81 | OPRL1 (0.53) | OPRL1OPRM1OPRD1OPRK1DRD2 | |
| SCHEMBL29588372 | 0.81 | SLC6A3 (0.53) | OPRL1OPRM1OPRD1OPRK1DRD2 | |
| SCHEMBL11802767 | 0.80 | OPRL1 (0.54) | OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL613615 | 0.79 | OPRM1 (0.45) | OPRL1OPRM1OPRD1OPRK1DRD2 | |
| SCHEMBL20455678 | 0.79 | SLC6A3 (0.56) | OPRL1OPRM1OPRD1OPRK1DRD2 | |
| SCHEMBL612855 | 0.77 | ESR2 (0.43) | DRD2 | |
| SCHEMBL24397813 | 0.76 | OPRL1 (0.49) | OPRL1OPRM1OPRD1OPRK1DRD2 | |
| SCHEMBL24398040 | 0.76 | P2RY14 (0.49) | OPRL1OPRM1OPRD1OPRK1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1107060-C | Piperazingl cyclohexanols and compositions containing same and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2003-04-30 | — | — | CN | disclosed |
| CN-1047594-C | Piperazinyl or piperidinyl cyclohexanols, their preparation and their use | BRISTOL MYERS SQUIBB CO (US) | 1999-12-22 | — | — | CN | disclosed |
| CN-1229796-A | Piperazingl cyclohexanols and compositions containing same and use thereof | BRISTOL MYERS SQUIBB CO (US) | 1999-09-29 | — | — | CN | disclosed |
| EP-0546583-B1 | Piperazinyl-and piperidinyl-cyclohexanols | BRISTOL MYERS SQUIBB CO (US) | 1996-05-22 | — | — | EP | disclosed |
| US-5478828-A | Anxiolytic agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-12-26 | — | — | US | disclosed |
| US-5387593-A | Anxiolytic agents | BRISTON-MYERS SQUIBB (US) | 1995-02-07 | — | — | US | disclosed |
| CN-1088923-A | Piperazinyl or piperamylcyclohexanol, preparation and use thereof | BRISTOL MYERS SQUIBB CO (US) | 1994-07-06 | — | — | CN | disclosed |
| EP-0546583-A1 | Piperazinyl-and piperidinyl-cyclohexanols | Bristol-Myers Squibb Company (US) | 1993-06-16 | — | — | EP | disclosed |
| US-3965180-A | CNS DEPRESSANT | THE UPJOHN COMPANY (US) | 1976-06-22 | — | — | US | disclosed |
| US-3960961-A | 4'-Fluoro-4-{[4-(phenyl)cyclohexyl]amino}butyrophenones and the salts thereof | THE UPJOHN COMPANY (US) | 1976-06-01 | — | — | US | disclosed |