Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.65 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.65 |
| ▸ | DRD2 | P14416 | 3/20 | 0.65 |
| ▸ | DRD4 | P21917 | 1/20 | 0.65 |
| ▸ | HTR2A | P28223 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9036734 | 0.99 | HTR1A (0.64) | HTR1AADRA1ADRD2DRD4HTR2A | |
| SCHEMBL9467179 | 0.94 | DRD2 (0.69) | HTR1ADRD2DRD4HTR2A | |
| Hydrochloric Acid SCHEMBL9035124 | 0.94 | DRD2 (0.68) | HTR1ADRD2DRD4HTR2A | |
| SCHEMBL9474121 | 0.94 | DRD2 (0.73) | HTR1AADRA1ADRD2DRD4HTR2A | |
| Hydrochloric Acid SCHEMBL9037059 | 0.93 | DRD2 (0.72) | HTR1AADRA1ADRD2DRD4HTR2A | |
| SCHEMBL9466381 | 0.87 | DRD2 (0.52) | HTR1AADRA1ADRD2DRD4HTR2A | |
| Hydrochloric Acid SCHEMBL9035828 | 0.86 | DRD2 (0.51) | HTR1AADRA1ADRD2DRD4HTR2A | |
| SCHEMBL9466203 | 0.85 | DRD3 (0.66) | HTR1ADRD2DRD4HTR2A | |
| SCHEMBL9036875 | 0.85 | DRD3 (0.66) | HTR1ADRD2DRD4HTR2A | |
| SCHEMBL9036862 | 0.85 | DRD3 (0.66) | HTR1ADRD2DRD4HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5225412-A | Antipsychotic | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-07-06 | — | — | US | claimed |
| EP-0511610-B1 | Benzisothiazole- and benzisoxazole-3-carboxamides, a process for their preparation and their use as antipsychotic medicaments | HOECHST ROUSSEL PHARMA (US) | 1996-09-11 | — | — | EP | disclosed |
| US-5225412-A | Antipsychotic | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-07-06 | — | — | US | disclosed |
| EP-0511610-A1 | Benzisothiazole- and benzisoxazole-3-carboxamides, a process for their preparation and their use as antipsychotic medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-11-04 | — | — | EP | disclosed |
| US-5143923-A | Psychological disorders | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1992-09-01 | — | — | US | disclosed |