Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AADAT | Q8N5Z0 | 6/20 | 0.36 |
| ▸ | GOT1 | P17174 | 1/20 | 0.36 |
| ▸ | KYAT1 | Q16773 | 1/20 | 0.36 |
| ▸ | KYAT3 | Q6YP21 | 1/20 | 0.36 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | CES1 | P23141 | 4/20 | 0.31 |
| ▸ | TTR | P02766 | 1/20 | 0.31 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.31 |
| ▸ | FEN1 | P39748 | 1/20 | 0.31 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.31 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8559311 | 0.76 | TLR9 (0.31) | TLR9ALDH1A1CES1TTR | |
| SCHEMBL6013602 | 0.76 | TTR (0.47) | KDM4EALDH1A1CES1TTR | |
| SCHEMBL2338193 | 0.73 | ALDH1A1 (0.50) | ALDH1A1GAACES1 | |
| SCHEMBL8555900 | 0.72 | CA12 (0.50) | KDM4EALDH1A1 | |
| SCHEMBL6013595 | 0.72 | ALDH1A1 (0.46) | KDM4EALDH1A1 | |
| SCHEMBL2228228 | 0.71 | OPRL1 (0.40) | — | |
| SCHEMBL8556011 | 0.69 | MEN1 (0.32) | KDM4EALDH1A1 | |
| SCHEMBL8087889 | 0.64 | CES1 (0.57) | ALDH1A1GAACES1TTRALDH2 | |
| SCHEMBL2354261 | 0.63 | TTR (0.41) | TLR9KDM4EALDH1A1CES1TTR | |
| SCHEMBL7985252 | 0.62 | TTR (0.53) | ALDH1A1CES1TTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0743855-A1 | 8-AZA, 6-AZA AND 6,8-DIAZA-1,4-DIHYDROQUINOXALINE-2,3-DIONES AND THE USE THEREOF AS ANTAGONISTS FOR THE GLYCINE/NMDA RECEPTOR | ACEA PHARMACEUTICALS, INC. (US) | 1996-11-27 | — | — | EP | disclosed |
| WO-1995018616-A2 | 8-AZA, 6-AZA AND 6,8-DIAZA-1,4-DIHYDROQUINOXALINE-2,3-DIONES AND THE USE THEREOF AS ANTAGONISTS FOR THE GLYCINE/NMDA RECEPTOR | ACEA PHARM INC (US) | 1995-07-13 | — | — | WO | disclosed |