Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.50 |
| ▸ | CA9 | Q16790 | 2/20 | 0.50 |
| ▸ | APEX1 | P27695 | 3/20 | 0.43 |
| ▸ | PTGES | O14684 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6013595 | 0.78 | ALDH1A1 (0.46) | CA12CA9MEN1KMT2AKDM4E | |
| SCHEMBL9618341 | 0.72 | CA12 (0.65) | CA12CA9APEX1PTGESMEN1 | |
| SCHEMBL9034857 | 0.72 | AADAT (0.36) | KDM4EALDH1A1 | |
| SCHEMBL30519490 | 0.71 | CES1 (0.65) | CA12CA9MEN1KMT2AALDH1A1 | |
| SCHEMBL3012558 | 0.71 | CES1 (0.65) | CA12CA9MEN1KMT2AALDH1A1 | |
| SCHEMBL2338193 | 0.69 | ALDH1A1 (0.50) | MEN1KMT2AALDH1A1MAPTHPGD | |
| SCHEMBL29744481 | 0.67 | CA12 (1.00) | CA12CA9MEN1KMT2AAKR1B1 | |
| SCHEMBL522649 | 0.67 | CA12 (1.00) | CA12CA9MEN1KMT2AAKR1B1 | |
| SCHEMBL3373741 | 0.67 | CA12 (0.53) | CA12CA9APEX1MEN1KMT2A | |
| SCHEMBL2228228 | 0.67 | OPRL1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0647137-A4 | GLYCINE RECEPTOR ANTAGONISTS AND THE USE THEREOF. | UNIV CALIFORNIA WEBER ECKARD (US) | 1998-09-16 | — | — | EP | disclosed |
| EP-0647137-A1 | GLYCINE RECEPTOR ANTAGONISTS AND THE USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1995-04-12 | — | — | EP | disclosed |