Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | DAO | P14920 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.45 |
| ▸ | HPN | P05981 | 3/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 4/20 | 0.42 |
| ▸ | F10 | P00742 | 4/20 | 0.42 |
| ▸ | PLG | P00747 | 4/20 | 0.42 |
| ▸ | PLAU | P00749 | 4/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.42 |
| ▸ | PLAT | P00750 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10215145 | 0.89 | ALDH1A1 (0.57) | ALDH1A1KDM4EMEN1MAPTKMT2A | |
| SCHEMBL903531 | 0.82 | CYP19A1 (0.50) | ALDH1A1KDM4EMEN1MAPTKMT2A | |
| SCHEMBL903497 | 0.79 | CYP19A1 (0.50) | ALDH1A1KDM4EMEN1MAPTKMT2A | |
| SCHEMBL903528 | 0.78 | HPN (0.38) | ALDH1A1KDM4EMEN1MAPTKMT2A | |
| SCHEMBL903538 | 0.78 | FLT3 (0.58) | ALDH1A1KDM4EMEN1MAPTKMT2A | |
| SCHEMBL11488198 | 0.78 | MEN1 (0.61) | ALDH1A1KDM4EMEN1MAPTKMT2A | |
| SCHEMBL6499820 | 0.74 | FFAR1 (0.62) | ALDH1A1KDM4EMEN1MAPTKMT2A | |
| SCHEMBL18817915 | 0.73 | HPN (0.72) | ALDH1A1KDM4EMEN1MAPTKMT2A | |
| SCHEMBL28167722 | 0.72 | MEN1 (0.61) | ALDH1A1KDM4EMEN1MAPTKMT2A | |
| SCHEMBL19889776 | 0.72 | CDK5 (0.51) | ALDH1A1KDM4EMEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012040923-A1 | TETRACYCLIC INDOLE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES | MERCK SHARP & DOHME CORP. (US) | 2012-04-05 | — | — | WO | disclosed |
| WO-2012041014-A1 | TETRACYCLIC INDOLE DERIVATIVES FOR TREATING HEPATITIS C VIRUS INFECTION | MERCK SHARP & DOHME CORP. (US) | 2012-04-05 | — | — | WO | disclosed |