Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPN | P05981 | 4/20 | 0.38 |
| ▸ | DAO | P14920 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.36 |
| ▸ | ASIC3 | Q9UHC3 | 2/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.34 |
| ▸ | F2 | P00734 | 2/20 | 0.34 |
| ▸ | F10 | P00742 | 2/20 | 0.34 |
| ▸ | PLG | P00747 | 2/20 | 0.34 |
| ▸ | PLAU | P00749 | 2/20 | 0.34 |
| ▸ | PLAT | P00750 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL903525 | 0.83 | CYP19A1 (0.47) | HPNDAOMAPTKDM4EMEN1 | |
| SCHEMBL903524 | 0.80 | KDM4E (0.50) | HPNMAPTKDM4EMEN1NPC1 | |
| SCHEMBL903527 | 0.78 | ALDH1A1 (0.46) | HPNDAOMAPTKDM4EMEN1 | |
| SCHEMBL903537 | 0.77 | MEN1 (0.46) | HPNDAOMAPTKDM4EMEN1 | |
| SCHEMBL903395 | 0.71 | CYP19A1 (0.49) | HPNDAOCYP19A1ASIC3FFAR1 | |
| SCHEMBL903541 | 0.69 | KDM4E (0.52) | HPNMAPTKDM4EMEN1NPC1 | |
| SCHEMBL10215145 | 0.66 | ALDH1A1 (0.57) | HPNDAOMAPTKDM4EMEN1 | |
| SCHEMBL27535931 | 0.66 | NOS1 (0.44) | DAOCDK5CDK5R1HRH4HRH3 | |
| SCHEMBL15889488 | 0.66 | CYP19A1 (0.46) | HPNDAOMAPTKDM4EMEN1 | |
| SCHEMBL7055030 | 0.64 | KDM4E (0.64) | MAPTKDM4EMEN1NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041014-A1 | TETRACYCLIC INDOLE DERIVATIVES FOR TREATING HEPATITIS C VIRUS INFECTION | MERCK SHARP & DOHME CORP. (US) | 2012-04-05 | — | — | WO | disclosed |
| WO-2012040923-A1 | TETRACYCLIC INDOLE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES | MERCK SHARP & DOHME CORP. (US) | 2012-04-05 | — | — | WO | disclosed |