Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 2/20 | 0.58 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 2/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | AXL | P30530 | 1/20 | 0.49 |
| ▸ | HPN | P05981 | 1/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | ITK | Q08881 | 1/20 | 0.45 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.44 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL903530 | 0.90 | KDM4E (0.60) | FLT3PDGFRBMEN1NPC1RAB9A | |
| SCHEMBL10215145 | 0.85 | ALDH1A1 (0.57) | MEN1NPC1RAB9AKMT2AKDM4E | |
| SCHEMBL903536 | 0.85 | FLT3 (0.53) | FLT3PDGFRBMEN1NPC1RAB9A | |
| SCHEMBL18817914 | 0.82 | HPN (0.68) | FLT3PDGFRBMEN1NPC1RAB9A | |
| SCHEMBL903524 | 0.80 | KDM4E (0.50) | FLT3PDGFRBMEN1NPC1RAB9A | |
| SCHEMBL15058186 | 0.80 | KDM4E (0.72) | FLT3PDGFRBMEN1NPC1RAB9A | |
| SCHEMBL903527 | 0.78 | ALDH1A1 (0.46) | MEN1NPC1RAB9AKMT2AKDM4E | |
| SCHEMBL11650959 | 0.78 | RAB9A (0.63) | FLT3PDGFRBMEN1NPC1RAB9A | |
| SCHEMBL903531 | 0.78 | CYP19A1 (0.50) | MEN1NPC1RAB9AKMT2AKDM4E | |
| SCHEMBL6117590 | 0.76 | KDM4E (0.71) | FLT3PDGFRBMEN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012040923-A1 | TETRACYCLIC INDOLE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES | MERCK SHARP & DOHME CORP. (US) | 2012-04-05 | — | — | WO | disclosed |
| WO-2012041014-A1 | TETRACYCLIC INDOLE DERIVATIVES FOR TREATING HEPATITIS C VIRUS INFECTION | MERCK SHARP & DOHME CORP. (US) | 2012-04-05 | — | — | WO | disclosed |