Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.58 |
| ▸ | NPC1 | O15118 | 5/20 | 0.58 |
| ▸ | RAB9A | P51151 | 5/20 | 0.58 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.57 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.54 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.54 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.54 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8399917 | 0.86 | SMN1; SMN2 (0.61) | SMN1; SMN2NPC1RAB9AMAPTMAPK1 | |
| SCHEMBL17934215 | 0.86 | MAPT (0.62) | SMN1; SMN2NPC1RAB9AMAPTMAPK1 | |
| SCHEMBL6969519 | 0.85 | MAPT (0.68) | SMN1; SMN2NPC1RAB9AMAPTMAPK1 | |
| SCHEMBL1009970 | 0.85 | ALDH1A1 (0.58) | TDP1SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL6938256 | 0.84 | MEN1 (0.55) | SMN1; SMN2NPC1RAB9AMAPTMAPK1 | |
| SCHEMBL4233854 | 0.83 | HCAR3 (0.60) | SMN1; SMN2NPC1RAB9AMAPTMAPK1 | |
| SCHEMBL10804569 | 0.82 | MEN1 (0.53) | SMN1; SMN2NPC1RAB9AMAPTMAPK1 | |
| SCHEMBL21815032 | 0.82 | MAPT (0.64) | TDP1SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL2472513 | 0.82 | KAT2B (0.60) | SMN1; SMN2NPC1RAB9AMAPTMAPK1 | |
| SCHEMBL29262827 | 0.82 | PKM (0.54) | SMN1; SMN2NPC1RAB9AMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0405442-B1 | 4,5-Dihydro-6H-imidazo[4,5,1-ij]quinolin-6-one-6-oxime-O-sulfonic acid derivatives | MOCHIDA PHARM CO LTD (JP) | 1996-09-04 | — | — | EP | disclosed |
| US-5151431-A | Diuretics | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1992-09-29 | — | — | US | disclosed |
| EP-0405442-A1 | 4,5-Dihydro-6H-imidazo[4,5,1-ij]quinolin-6-one-6-oxime-O-sulfonic acid derivatives | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1991-01-02 | — | — | EP | disclosed |