Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | TTR | P02766 | 5/20 | 0.47 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PGR | P06401 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CBR1 | P16152 | 1/20 | 0.47 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3075754 | 0.80 | PIM1 (0.64) | PIM1TTRMAPTHPGDCA12 | |
| SCHEMBL3914588 | 0.73 | KDM4E (0.69) | PIM1LMNAMAPTHPGDCA12 | |
| SCHEMBL10340778 | 0.73 | TTR (0.62) | TTRNR1I2LMNAPGRHSP90AA1 | |
| SCHEMBL10489722 | 0.71 | LMNA (0.53) | TTRNR1I2LMNAPGRHSP90AA1 | |
| SCHEMBL5346628 | 0.71 | ALDH1A1 (0.68) | PIM1TTRLMNAMAPTHPGD | |
| SCHEMBL23116723 | 0.70 | PIM1 (0.54) | PIM1MAPTHPGDCA12CA1 | |
| SCHEMBL27787867 | 0.70 | KDM4E (0.71) | PIM1MAPTHPGDCA12CA1 | |
| SCHEMBL6189052 | 0.70 | PIM1 (0.54) | PIM1MAPTHPGDCA12CA1 | |
| SCHEMBL3469104 | 0.69 | TTR (0.61) | TTRNR1I2LMNAPGRHSP90AA1 | |
| SCHEMBL27582367 | 0.69 | CA12 (0.58) | PIM1HPGDCA12CA1CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0442655-B1 | Benzisoxazole derivatives | ZENECA LTD (GB) | 1996-01-17 | — | — | EP | disclosed |
| US-5176737-A | BENZISOXAZOLE COMPOUNDS USEFUL AS HERBICIDES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-01-05 | — | — | US | disclosed |
| EP-0442655-A2 | Benzisoxazole derivatives | ZENECA LIMITED (GB) | 1991-08-21 | — | — | EP | disclosed |