Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | ELANE | P08246 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL852512 | 0.81 | ELANE (0.41) | MAPTELANETDP1KDM4EATM | |
| SCHEMBL4544920 | 0.76 | TDP1 (0.48) | MAPTELANETDP1KDM4EATM | |
| SCHEMBL735728 | 0.74 | TDP1 (0.47) | MAPTELANETDP1KDM4EATM | |
| Propane SCHEMBL3801023 | 0.74 | MAPT (0.48) | MAPTELANETDP1ATML3MBTL1 | |
| SCHEMBL10751774 | 0.73 | TDP1 (0.42) | MAPTELANETDP1KDM4EATM | |
| SCHEMBL10411906 | 0.72 | TDP1 (0.45) | MAPTELANETDP1KDM4EATM | |
| SCHEMBL7499252 | 0.72 | ATM (0.45) | MAPTELANETDP1KDM4EATM | |
| SCHEMBL505224 | 0.72 | THRA (0.49) | MAPTELANETDP1KDM4EATM | |
| SCHEMBL45119 | 0.72 | ELANE (0.72) | MAPTELANETDP1ATML3MBTL1 | |
| Benzene SCHEMBL28089483 | 0.72 | ELANE (0.72) | MAPTELANETDP1ATML3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0491943-A4 | TETRAHYDROPYRIDOINDOLES AS CHOLECYSTOKININ AND GASTRIN ANTAGONISTS | RORER INT HOLDINGS (US) | 1996-02-14 | — | — | EP | disclosed |
| US-5340801-A | Compounds having cholecystokinin and gastrin antagonistic properties | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1994-08-23 | — | — | US | disclosed |
| EP-0491943-A1 | TETRAHYDROPYRIDOINDOLES AS CHOLECYSTOKININ AND GASTRIN ANTAGONISTS | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1992-07-01 | — | — | EP | disclosed |
| WO-1992000295-A1 | TETRAHYDROPYRIDOINDOLES AS CHOLECYSTOKININ AND GASTRIN ANTAGONISTS | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1992-01-09 | — | — | WO | disclosed |