Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GP6 | Q9HCN6 | 1/20 | 0.44 |
| ▸ | AGTR1 | P30556 | 12/20 | 0.43 |
| ▸ | AGTR2 | P50052 | 11/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9036532 | 0.95 | AGTR2 (0.42) | GP6AGTR1AGTR2 | |
| SCHEMBL9035938 | 0.94 | GP6 (0.43) | GP6AGTR1AGTR2 | |
| SCHEMBL9036890 | 0.93 | AGTR2 (0.38) | GP6AGTR1AGTR2 | |
| SCHEMBL9035246 | 0.93 | AGTR1 (0.43) | GP6AGTR1AGTR2 | |
| SCHEMBL9035915 | 0.93 | GP6 (0.47) | GP6AGTR1AGTR2 | |
| SCHEMBL9035747 | 0.93 | GP6 (0.47) | GP6AGTR1AGTR2 | |
| SCHEMBL9553971 | 0.92 | GP6 (0.46) | GP6AGTR1AGTR2 | |
| SCHEMBL9034829 | 0.92 | AGTR2 (0.40) | GP6AGTR1AGTR2 | |
| SCHEMBL9034937 | 0.92 | AGTR1 (0.47) | GP6AGTR1AGTR2 | |
| SCHEMBL9704951 | 0.91 | GP6 (0.38) | GP6AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0555331-B1 | N-SUBSTITUTED IMIDAZOL-2-ONE COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS | SEARLE & CO (US) | 1996-04-24 | — | — | EP | claimed |
| EP-0236931-B1 | Aromatic omega-alkylimino-tetrahydro-6H-1,3-Thiazin-6-one derivatives | MERRELL DOW PHARMA (US) | 1993-12-29 | — | — | EP | claimed |
| EP-0555331-B1 | N-SUBSTITUTED IMIDAZOL-2-ONE COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS | SEARLE & CO (US) | 1996-04-24 | — | — | EP | disclosed |
| EP-0530225-A4 | INTERMEDIATES IN THE FORMATION OF THE CALICHEAMICIN AND ESPERAMICIN OLIGOSACCHARIDES | — | 1993-09-22 | — | — | EP | disclosed |
| US-5238952-A | Treating glaucoma disorders | G. D. SEARLE & CO. (US) | 1993-08-24 | — | — | US | disclosed |
| EP-0555331-A1 | N-SUBSTITUTED IMIDAZOL-2-ONE COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS. | SEARLE & CO (US) | 1993-08-18 | — | — | EP | disclosed |
| EP-0530225-A1 | INTERMEDIATES IN THE FORMATION OF THE CALICHEAMICIN AND ESPERAMICIN OLIGOSACCHARIDES | THE SCRIPPS RESEARCH INSTITUTE (US) | 1993-03-10 | — | — | EP | disclosed |
| WO-1992007834-A1 | N-SUBSTITUTED IMIDAZOL-2-ONE COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS | G.D. SEARLE & CO. (US) | 1992-05-14 | — | — | WO | disclosed |
| US-5087634-A | N-substituted imidazol-2-one compounds for treatment of circulatory disorders | G. D. SEARLE & CO. (US) | 1992-02-11 | — | — | US | disclosed |
| WO-1991017158-A1 | INTERMEDIATES IN THE FORMATION OF THE CALICHEAMICIN AND ESPERAMICIN OLIGOSACCHARIDES | SCRIPPS CLINIC AND RESEARCH FOUNDATION (US) | 1991-11-14 | — | — | WO | disclosed |