Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ACHE | P22303 | 6/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | POLL | Q9UGP5 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 4/20 | 0.34 |
| ▸ | DRD1 | P21728 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8740800 | 0.78 | KDM4E (0.55) | KDM4EACHECYP1A2ALDH1A1GLA | |
| SCHEMBL14142398 | 0.76 | ACHE (0.76) | KDM4EACHECYP1A2ALDH1A1GLA | |
| SCHEMBL9458166 | 0.73 | KDM4E (0.53) | KDM4EACHECYP1A2ALDH1A1GLA | |
| SCHEMBL11876427 | 0.71 | ACHE (0.63) | KDM4EACHEALDH1A1GLAGAA | |
| SCHEMBL7359720 | 0.69 | KDM4E (0.62) | KDM4EACHECYP1A2ALDH1A1GLA | |
| SCHEMBL9036025 | 0.64 | KDM4E (1.00) | KDM4EACHECYP1A2ALDH1A1GLA | |
| SCHEMBL31321876 | 0.64 | KDM4E (1.00) | KDM4EACHECYP1A2ALDH1A1GLA | |
| SCHEMBL11869676 | 0.62 | ACHE (1.00) | KDM4EACHEALDH1A1GLAGAA | |
| SCHEMBL2062216 | 0.62 | CYP1A2 (0.48) | KDM4ECYP1A2ALDH1A1GAAHPGD | |
| SCHEMBL23023380 | 0.62 | KDM4E (0.81) | KDM4EACHECYP1A2ALDH1A1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0422134-B1 | 5-HT SELECTIVE AGENTS | ABBOTT LAB (US) | 1996-06-12 | — | — | EP | disclosed |
| US-5049564-A | Hypotensive, 5-hydroxytryptamine | ABBOTT LABORATORIES (US) | 1991-09-17 | — | — | US | disclosed |
| EP-0422134-A1 | 5-HT SELECTIVE AGENTS. | ABBOTT LAB (US) | 1991-04-17 | — | — | EP | disclosed |
| WO-1990006927-A1 | 5-HT SELECTIVE AGENTS | ABBOTT LABORATORIES (US) | 1990-06-28 | — | — | WO | disclosed |