Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TOP2A | P11388 | 8/20 | 0.42 |
| ▸ | TOP2B | Q02880 | 8/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | ALB | P02768 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | AADAT | Q8N5Z0 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.41 |
| ▸ | TUBB | P07437 | 1/20 | 0.41 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.41 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.41 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.41 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9582926 | 1.00 | KDM4E (0.50) | KDM4ESMN1; SMN2CYP1A2LMNAKMT2A | |
| SCHEMBL10998166 | 0.88 | KDM4E (0.60) | KDM4ESMN1; SMN2CYP1A2LMNAKMT2A | |
| SCHEMBL11002928 | 0.88 | LMNA (0.56) | KDM4ESMN1; SMN2CYP1A2LMNAKMT2A | |
| SCHEMBL9703818 | 0.85 | KDM4E (0.48) | KDM4ESMN1; SMN2CYP1A2LMNAKMT2A | |
| SCHEMBL11164745 | 0.84 | KDM4E (0.46) | KDM4ESMN1; SMN2CYP1A2LMNAKMT2A | |
| SCHEMBL10432962 | 0.83 | KDM4E (0.43) | KDM4ESMN1; SMN2CYP1A2LMNAKMT2A | |
| SCHEMBL11160975 | 0.82 | KDM4E (0.57) | KDM4ESMN1; SMN2CYP1A2LMNAKMT2A | |
| SCHEMBL11166942 | 0.81 | LMNA (0.50) | KDM4ESMN1; SMN2CYP1A2LMNATOP2A | |
| SCHEMBL11166414 | 0.81 | LMNA (0.49) | KDM4ESMN1; SMN2CYP1A2LMNAKMT2A | |
| SCHEMBL9582803 | 0.80 | LMNA (0.58) | KDM4ESMN1; SMN2CYP1A2LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0390135-B1 | Pyrroloquinoline derivatives, antimicrobial agents using the same and process for preparing the same | OTSUKA PHARMA CO LTD (JP) | 1996-06-05 | — | — | EP | disclosed |
| US-5185337-A | Pyrroloquinoline derivatives and pharmaceutical compositions for antimicrobial use | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1993-02-09 | — | — | US | disclosed |
| EP-0390135-A1 | Pyrroloquinoline derivatives, antimicrobial agents using the same and process for preparing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1990-10-03 | — | — | EP | disclosed |