Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCKDK | O14874 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
| ▸ | CHUK | O15111 | 1/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.39 |
| ▸ | PRKACG | P22612 | 1/20 | 0.39 |
| ▸ | PRKACB | P22694 | 1/20 | 0.39 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2610279 | 0.84 | GPR35 (0.51) | BCKDKKDM4EMAPTALDH1A1HPGD | |
| SCHEMBL16096210 | 0.75 | GPR35 (0.42) | KDM4EMAPTALDH1A1HPGDGPR35 | |
| SCHEMBL3189439 | 0.74 | ALDH1A1 (0.49) | KDM4EMAPTALDH1A1HPGDIKBKB | |
| SCHEMBL15517623 | 0.73 | ALDH1A1 (0.38) | KDM4EMAPTALDH1A1HPGDGPR35 | |
| SCHEMBL2960466 | 0.71 | BCKDK (0.67) | BCKDKKDM4EMAPTALDH1A1HPGD | |
| SCHEMBL25205759 | 0.70 | ALDH1A1 (0.68) | KDM4EMAPTALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL31015990 | 0.70 | ALDH1A1 (0.68) | KDM4EMAPTALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL30968548 | 0.69 | KDM4E (0.78) | KDM4EMAPTALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL14954934 | 0.69 | KDM4E (0.78) | KDM4EMAPTALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL20695458 | 0.68 | BCKDK (0.58) | BCKDKKDM4EALDH1A1HPGDGPR35 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0511610-B1 | Benzisothiazole- and benzisoxazole-3-carboxamides, a process for their preparation and their use as antipsychotic medicaments | HOECHST ROUSSEL PHARMA (US) | 1996-09-11 | — | — | EP | disclosed |
| US-5225412-A | Antipsychotic | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-07-06 | — | — | US | disclosed |
| EP-0511610-A1 | Benzisothiazole- and benzisoxazole-3-carboxamides, a process for their preparation and their use as antipsychotic medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-11-04 | — | — | EP | disclosed |
| US-5143923-A | Psychological disorders | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1992-09-01 | — | — | US | disclosed |