Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.44 |
| ▸ | CDK7 | P50613 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.44 |
| ▸ | TYMS | P04818 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 3/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.42 |
| ▸ | PRKDC | P78527 | 2/20 | 0.42 |
| ▸ | ATR | Q13535 | 2/20 | 0.42 |
| ▸ | ATRIP | Q8WXE1 | 2/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1599017 | 0.79 | TYMS (0.39) | ABL1PDGFRACSNK1A1CDK7BTK | |
| SCHEMBL9037537 | 0.77 | BRD4 (0.37) | ATMPIK3CBPRKDCATRATRIP | |
| SCHEMBL10885012 | 0.75 | PRKDC (0.51) | ATMPIK3CBPRKDCATRATRIP | |
| SCHEMBL9040622 | 0.71 | ALDH1A1 (0.36) | ATMPIK3CBPRKDCATRATRIP | |
| SCHEMBL9036947 | 0.71 | POLB (0.46) | MAPTPOLB | |
| SCHEMBL13579619 | 0.70 | KDR (0.51) | ABL1PDGFRACSNK1A1CDK7BTK | |
| SCHEMBL9036696 | 0.69 | GRIN2D (0.46) | ATMPIK3CBPRKDCATRATRIP | |
| SCHEMBL29822889 | 0.68 | GAA (0.53) | ABL1CDK7MAP4K2AURKBCLK4 | |
| SCHEMBL11101911 | 0.64 | PDE2A (0.47) | GAAMAPTKDM4EMEN1NPC1 | |
| SCHEMBL30498958 | 0.64 | SMN1; SMN2 (0.64) | ABL1PDGFRACSNK1A1CDK7BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0518530-B1 | Improvements in or relating to excitatory amino acid receptor antagonists | LILLY CO ELI (US) | 1996-10-09 | — | — | EP | disclosed |
| US-5196421-A | Treatment of neurological disorders | ELI LILLY AND COMPANY (US) | 1993-03-23 | — | — | US | disclosed |
| EP-0518530-A2 | Improvements in or relating to excitatory amino acid receptor antagonists | ELI LILLY AND COMPANY (US) | 1992-12-16 | — | — | EP | disclosed |
| US-5153196-A | Administering for reduction of neurotransmission in nervous system disorders | ELI LILLY AND COMPANY (US) | 1992-10-06 | — | — | US | disclosed |