Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 2/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.30 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.30 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.30 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.30 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.30 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.30 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30204428 | 0.79 | — | — | |
| SCHEMBL30204358 | 0.75 | PRPS1 (0.33) | — | |
| SCHEMBL15572246 | 0.73 | DGAT1 (0.40) | DGAT1 | |
| SCHEMBL15368135 | 0.73 | DGAT1 (0.40) | DGAT1 | |
| SCHEMBL15471725 | 0.72 | DGAT1 (0.41) | DGAT1 | |
| Hydrochloric Acid SCHEMBL535924 | 0.71 | L3MBTL1 (0.34) | DGAT1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL13070718 | 0.71 | TAAR1 (0.33) | DGAT1 | |
| SCHEMBL16105981 | 0.69 | TAAR1 (0.36) | DGAT1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL16105980 | 0.69 | TAAR1 (0.36) | DGAT1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL30889433 | 0.69 | DGAT1 (0.37) | DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041014-A1 | TETRACYCLIC INDOLE DERIVATIVES FOR TREATING HEPATITIS C VIRUS INFECTION | MERCK SHARP & DOHME CORP. (US) | 2012-04-05 | — | — | WO | disclosed |
| WO-2011112429-A1 | FUSED TRICYCLIC SILYL COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES | SCHERING CORPORATION (US) | 2011-09-15 | — | — | WO | disclosed |