Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.51 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.51 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.51 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.51 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.51 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | EDNRA | P25101 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HTR2B | P41595 | 1/20 | 0.51 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.51 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9035906 | 1.00 | PPARG (0.51) | PPARGAGTR1LTB4R2ACHEABCC3 | |
| SCHEMBL9035903 | 0.86 | AGTR1 (0.49) | AGTR1LTB4R2ABCC3ABCC4ABCB11 | |
| SCHEMBL8958371 | 0.85 | AGTR1 (0.54) | AGTR1LTB4R2ABCC3ABCC4ABCB11 | |
| SCHEMBL8958378 | 0.85 | AGTR1 (0.54) | AGTR1LTB4R2ABCC3ABCC4ABCB11 | |
| SCHEMBL8958364 | 0.85 | AGTR1 (0.54) | AGTR1LTB4R2ABCC3ABCC4ABCB11 | |
| SCHEMBL9464252 | 0.81 | AGTR1 (0.50) | AGTR1LTB4R2ABCC3ABCC4ABCB11 | |
| SCHEMBL9464258 | 0.81 | AGTR1 (0.50) | AGTR1LTB4R2ABCC3ABCC4ABCB11 | |
| SCHEMBL9464251 | 0.81 | AGTR1 (0.50) | AGTR1LTB4R2ABCC3ABCC4ABCB11 | |
| SCHEMBL21083908 | 0.78 | AGTR1 (0.61) | AGTR1LTB4R2ACHEABCC3ABCC4 | |
| SCHEMBL8958455 | 0.77 | ACHE (0.73) | AGTR1LTB4R2ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0501892-B1 | Diazotized heterocyclic derivatives N-substituted by a biphenylmethyl group, their preparation and pharmaceutical compositions containing them | SANOFI SA (FR) | 1996-07-24 | — | — | EP | claimed |
| US-5268375-A | Dinitrogen heterocyclic derivatives N-substituted by a biphenylmethyl group, and the pharmaceutical compositions in which they are present | ELF SANOFI (FR) | 1993-12-07 | — | — | US | disclosed |