Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1383225 | 0.89 | ALDH1A1 (0.44) | SMN1; SMN2NOTUMPOLBSIGMAR1MEN1 | |
| SCHEMBL28654768 | 0.83 | SMN1; SMN2 (0.46) | SMN1; SMN2NOTUMPOLBRECQLSIGMAR1 | |
| SCHEMBL29206272 | 0.77 | POLB (0.47) | SMN1; SMN2NOTUMPOLBRECQLSIGMAR1 | |
| SCHEMBL14625026 | 0.77 | NOTUM (0.50) | SMN1; SMN2NOTUMPOLBRECQLSIGMAR1 | |
| SCHEMBL1716131 | 0.75 | SMN1; SMN2 (0.56) | SMN1; SMN2NOTUMPOLBRECQLSIGMAR1 | |
| SCHEMBL27745558 | 0.75 | SMN1; SMN2 (0.56) | SMN1; SMN2NOTUMPOLBRECQLSIGMAR1 | |
| SCHEMBL1859866 | 0.73 | SMN1; SMN2 (0.54) | SMN1; SMN2NOTUMPOLBRECQLSIGMAR1 | |
| SCHEMBL10440938 | 0.73 | NOTUM (0.59) | SMN1; SMN2NOTUMPOLBRECQLMEN1 | |
| SCHEMBL5263502 | 0.73 | SMN1; SMN2 (0.46) | SMN1; SMN2NOTUMPOLBRECQLSIGMAR1 | |
| Hydrochloric Acid SCHEMBL1859868 | 0.73 | SMN1; SMN2 (0.54) | SMN1; SMN2NOTUMPOLBRECQLSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0702004-A2 | 2,9-diamino- and 2-amino-8-carbamoyl-4-hydroxy-alkanoic acid amid derivatives | CIBA-GEIGY AG (CH) | 1996-03-20 | — | — | EP | disclosed |
| EP-0386839-A2 | Tetrahydroquinoline derivatives useful for neurodegenerative disorders | MERCK SHARP & DOHME LTD. (GB) | 1990-09-12 | — | — | EP | disclosed |